Skip to main content
Log in

The ultrastructure of the thin loop limbs of the mouse kidney

  • Published:
Anatomy and Embryology Aims and scope Submit manuscript

Summary

The thin limbs of the loops of Henle in the mouse kidney have been investigated by conventional electron microscopy. Resulting from light microscopic investigations, a distinction in the epithelia of short and long loops can be demonstrated. Ultrastructurally, the thin limbs (descending) of short loops are composed of a uniformly thin and simple epithelium. In contrast, long loops (thin descending and ascending) are composed of three different epithelial types which are representative of a distinctly more complex epithelial system. Two epithelial types were observed in the thin descending limbs of long loops and the third type was observed in the ascending thin limbs. Based upon these findings it is suggested that the thin descending limbs of short and long loops of Henle in the mouse kidney cannot perform the same functions in the renal concentrating mechanism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bulger, R. E., Trump, B. F.: Fine structure of the rat renal papilla. Amer. J. Anat.118, 685–722 (1966)

    Google Scholar 

  • Dieterich, H. J.: Die Ultrastruktur der Gefäßbündel im Mark der Rattenniere. Z. Zellforsch.84, 350–371 (1968)

    Google Scholar 

  • Dieterich, H. J., Kriz, W.: Zum Problem der Fixierung des Nierenmarks. Licht- und elektronenmikroskopische Untersuchungen an der Außenzone der Rattenniere. Acta anat. (Basel)74, 267–289 (1969)

    Google Scholar 

  • Imai, M., Kokko, J. P.: Sodium chloride, urea, and water transport in the thin ascending limb of Henle. Generation of osmotic gradients by passive diffusion of solutes. J. clin. Invest.53, 393–402 (1974)

    Google Scholar 

  • Koepsell, H., Kriz, W., Schnermann, J.: Pattern of luminal diameter changes along the descending and ascending thin limbs of the loop of Henle in the inner medullary zone of the rat kidney. Z. Anat. Entwickl.-Gesch.138, 321–328 (1972)

    Google Scholar 

  • Kokko, J. P.: Membrane characteristics governing salt and water transport in the loop of Henle. Fed. Proc.33, 25–30 (1974)

    Google Scholar 

  • Kokko, J. P., Rector, Jr. F. C.: Countercurrent multiplication system without active transport in inner medulla. Kidney int.2, 214–233 (1972)

    Google Scholar 

  • Kriz, W., Lever, A. F.: Renal countercurrent mechanisms: Structure and function. Amer. Heart J.78, 101–118 (1969)

    Google Scholar 

  • Kriz, W., Schnermann, J., Dieterich, H. J.: Differences in the morphology of descending limbs of short and long loops of Henle in the rat kidney. In: Wirz, H., Spinelli, F. (eds.), Recent advances in renal physiology, p. 140–144, Basel: S. Karger, 1972a

    Google Scholar 

  • Kriz, W., Schnermann, J., Koepsell, H.: The position of short and long loops of Henle in the rat kidney. Z. Anat. Entwickl.-Gesch.138, 301–319 (1972b)

    Google Scholar 

  • Lapp, H., Nolte, A.: Vergleichende elektronenmikroskopische Untersuchungen am Mark der Rattenniere bei Harnkonzentrierung und Harnverdünnung. Frankfurt. Z. Path.71, 617–633 (1962)

    Google Scholar 

  • Latta, H., Maunsbach, A. B., Osvaldo, L.: The fine structure of renal tubules in cortex and medulla. In: Dalton, A. J., haguenau, F. (eds.), Ultrastructure of the kidney, p. 1–56. New York and London: Academic Press 1967

    Google Scholar 

  • Luft, J. H.: Improvements in epoxy resin embedding methods. J. biophys. biochem. Cytol.9, 409–414 (1961)

    Google Scholar 

  • Marsh, D. J.: Solute and water flows in thin limbs of Henle's loop in the hamster kidney. Amer. J. Physiol.218, 824–831 (1970)

    Google Scholar 

  • Marsh, D. J.: Osmotic concentration and dilution of the urine. In: Rouiller, C., Muller, A. F. (eds.), The kidney. Morphology, biochemistry, physiology, vol. III, p. 71–126, New York and London: Academic Press 1971

    Google Scholar 

  • Osvaldo, L., Latta, H.: The thin limbs of the loop of Henle. J. Ultrastruct. Res.15, 144–168 (1966)

    Google Scholar 

  • Palatt, P. J., Saidel, G. M.: Countercurrent exchange in the inner renal medulla: Vasa recta-descending limb system. Bull. math. Biol.35, 431–447 (1973)

    Google Scholar 

  • Pennell, J. P., Laey, F. B., Jamison, R. L.: An in vivo study of the concentrating process in the descending limb of Henle's loop. Kidney int.5, 337–347 (1974)

    Google Scholar 

  • Reynolds, E. S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol.17, 208–212 (1963)

    Google Scholar 

  • Rhodin, J.: Anatomy of kidney tubules. Int. Rev. Cytol.7, 485–534 (1958)

    Google Scholar 

  • Richardson, K. C., Jarett, L., Finke, E. H.: Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol.35, 313–323 (1960)

    Google Scholar 

  • Rouffignac, C. de: Physiological role of the loop of Henle in urinary concentration. Kidney int.2, 297–303 (1972)

    Google Scholar 

  • Steinhausen, M.: In vivo-Beobachtungen an der Nierenpapille von Goldhamstern nach intravenöser Lissamingrün-Injektion. Pflügers Arch. ges. Physiol.279, 195–213 (1964)

    Google Scholar 

  • Stephenson, J. L.: Concentration of urine in a central core model of the renal counterflow system. Kidney int.2, 85–94 (1972)

    Google Scholar 

  • Stewart, J., Valtin, H.: Computer simulation of osmotic gradient without active transport in renal inner medulla. Kidney int.2, 264–270 (1972)

    Google Scholar 

  • Wirz, H.: Die Niere als Regulator des osmotischen Druckes. Mod. Probl. Pädiat.6, 86–98 (1960)

    Google Scholar 

  • Wohlfarth-Bottermann, K. E.: Die Kontrastierung tierischer Zellen und Gewebe im Rahmen ihrer elektronenmikroskopischen Untersuchung an ultradünnen Schnitten. Naturwissenschaften44, 287–288 (1957)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Stipendiat der Alexander v. Humboldt-Stiftung.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dieterich, H.J., Barrett, J.M., Kriz, W. et al. The ultrastructure of the thin loop limbs of the mouse kidney. Anat. Embryol. 147, 1–18 (1974). https://doi.org/10.1007/BF00317960

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00317960

Key words

Navigation