Summary
The inheritance and some developmental effects of a new allele of ocular retardation (or J) are described. Affected animals, at 12 days of gestation, show reduced cell death in the eye cup and thickening of the inner wall of the optic fissure. At 11 to 13 days of gestation or 3/or J eyes grafted to the testis do not produce retina as their or J+ littermates do. Adult animals have small eyes with closed lids, abnormal retinal layers, and no optic nerve.
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This investigation was supported in part by NIH Research Grant CA 02662 from the National Cancer Institute. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.
The assistance of Miss Erni and Dr Groscurth in preparing the EM pictures is ackowledged.
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Theiler, K., Varnum, D.S., Nadeau, J.H. et al. A new allele of ocular retardation: Early development and morphogenetic cell death. Anat. Embryol. 150, 85–97 (1976). https://doi.org/10.1007/BF00346288
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DOI: https://doi.org/10.1007/BF00346288