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Development of Coloboma (Cm/+), a mutation with anterior lens adhesion

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Summary

A semidominant mutation in the laboratory mouse, Coloboma (Cm), is described. Coloboma is located on Chromosome 2, as is the similar mutation Dickie's small eye (Dey). Coloboma has a moderately reduced expressivity. The anterior chamber is usually present in Cm/+. Both Cm and Dey show delayed detachment of the lens vesicle and microphthalmia, and homozygotes of both apparently die early in prenancy.

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Authors and Affiliations

  1. Anatomisches Institut der Universität, Gloriastr. 19, CH-8006, Zürich, Switzerland

    Karl Theiler

  2. The Jackson Laboratory, 04609, Bar Harbor, Maine, USA

    Don S. Varnum

Authors
  1. Karl Theiler
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  2. Don S. Varnum
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Additional information

This work was supported by research grant CA 02662 from the National Cancer Institute

The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care

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Theiler, K., Varnum, D.S. Development of Coloboma (Cm/+), a mutation with anterior lens adhesion. Anat Embryol 162, 121–126 (1981). https://doi.org/10.1007/BF00318098

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  • DOI: https://doi.org/10.1007/BF00318098

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