Summary
The present study described the normal ultrastructure of the monkey pineal gland. The gland was composed of the principal pinealocytes, intramural neurons and glial cells. The nucleus of the pinealocytes was deeply infolded with evenly distributed chromatin materials. The abundant cytoplasm was rich in organelles including the well-developed Golgi apparatuses, multivesicular bodies, dense-cored vesicles and widely scattered free and polyribosomes. A variety of axon terminals was observed and the majority of them contained pleomorphic agranular vesicles with a few large dense-cored vesicles. A few terminals showed flattened vesicles or small dense cored vesicles. Some of the axon terminals formed synaptic contacts with the cell bodies of pinealocytes. These synapses were mainly concentrated in the posterior third of the gland. The occasional intramural neurons observed were postsynaptic to axon terminals containing round agranular vesicles. The sources of the nerve fibres and terminals forming synaptic junctions with pinealocytes and intramural neurons were discussed.
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References
Calvo J, Boya J (1984) Ultrastructure of the pineal gland in the adult rat. J Anat 138:405–409
Chang N, Phatnogar KP, Tseng MT, Karim KB (1987) Ultrastructure of the pineal gland of the tropical bat Rousettus leschenaulti. Acta Anat 128:194–203
David GFX, Herbert J (1973) Experimental evidence for a synaptic connection between habenula and pineal ganglion in the ferret. Brain Res 64:323–343
David GFX, Herbert J, Wright GDS (1973) The ultrastructure of the pineal ganglion in the ferret. J Anat 115:79–97
Huang HT, Lin HS (1984) Synaptic junctions between the adrenergic axon varicosity and the pinealocyte in the rat. J Pineal Res 1:281–291
Huang SK, Taugner R (1984) Gap junctions between guinea-pig pinealocytes. Cell Tissue Res 235:137–141
Ichimura T, Arikuni T, Hashimoto PH (1986) Fine-structural study of the pineal body of the monkey (Macaca fuscata) with special reference to synaptic formations. Cell Tissue Res 244:569–576
Kappers JA (1979) Short history of pineal discovery and research. Prog Brain Res 52:3–22
Karasek M, Hansen JT (1982) Ultrastructure of the pineal gland of the fox. Am J Anat 163:257–267
Kenny GCT (1961) The “nervus conarii” of the monkey. An experimental study. J Neuropathol Exp Neurol 20:563–570
Luo ZR, Schultz RL, Whitter EF, Vollrath L (1984) Ultrastructural characterization of glial cells in the rat pineal gland with special reference to the pineal stalk. Anat Rec 210:663–674
Matsushima S, Reiter RJ (1977) Fine structural features of adrenergic nerve fibres and endings in the pineal gland of the rat, ground squirrel and chinchilla. Am J Anat 148:463–478
Møller M (1978) Presence of a pineal nerve (nervus pinealis) in the human fetus; a light and electron microscopical study of the innervation of the pineal gland. Brain Res 154:1–12
Møller M (1985) Non-sympathetic synaptic innervation of the pinealocyte of the Mongolian gerbil (Meriones unguiculatus): an electron microscopic study. J Neurocytol 14:541–550
Møller M, Korf HW (1983) The origin of central pinealopetal nerve fibres in the Mongolian gerbil as demonstrated by the retrograde transport of horseradish peroxidase. Cell Tissue Res 230:273–287
Mori S, Leblond CP (1969) Identification of microglia in light and electron microscopy. J Comp Neurol 135:57–80
Nielsen JY, Møller M (1975) Nervous connections between the brain and the pineal gland in the cat (Felis catus) and the monkey (Cercopithecus aethiops). Cell Tissue Res 161:293–302
Peters A, Palay S, Webster H deF (1976) The Fine Structure of the Nervous System: The Neurons and Supporting Cells, Saunders WB, Philadelphia London Toronto
Povlishock JT, Kriebel RM, Seibel HR (1975) A light and electron microscopic study on the pineal gland of the ground squirrel, Citellus tridecemblinatus. Am J Anat 143:465–484
Romijn HJ (1973 a) Structure and innervation of the pineal gland of the rabbit, Oryctolagus cuniculus (L.). I. A light microscopic investigation. Z Zellforsch 139:473–485
Romijn HJ (1973 b) Structure and innervation of the pineal gland of the rabbit, Oryctolagus cuniculus (L.). II. An electron microscopic investigation of the pinealocytes. Z. Zellforsch 141:545–560
Romijn HJ (1973 c) Parasympathetic innervation of the rabbit pineal gland. Brain Res 55:431–436
Romijn HT (1975) Structure and innervation of the pineal gland of the rabbit, Oryctolagus cuniculus (L.). III. An electron microscopic investigation of the innervation. Cell Tissue Res 157:25–51
Sheridan MN, Reiter RJ (1968) The fine structure of the hamster pineal gland. Am J Anat 122:357–376
Sheridan MN, Reiter RJ (1973) The fine structure of the pineal gland in the pocket Gopher, Geomys bursarius. Am J Anat 136:363–382
Ueck M (1979) Innervation of the vertebrate pineal. Prog Brain Res 52:45–88
Ueck M, Wake K (1979) The pinealocyte — a paraneuron. Prog Brain Res 52:141–147
Vollrath L (1981) The pineal organ. In: Oksche A, Vollrath L (eds) Handbuch der Mikroskopischen Anatomie des Menschen VI/7. Springer, Berlin Heidelberg New York
Wood JG (1973) The effect of niamid and reserpine or the nerve endings of the pineal gland. Z Zellforsch 145:151–166
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Ling, E.A., Tan, S.H., Yick, T.Y. et al. Ultrastructure of the pineal gland of the monkey, Macaca fascicularis, with special reference to the presence of synaptic junctions on pinealocytes. Anat Embryol 180, 151–158 (1989). https://doi.org/10.1007/BF00309766
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DOI: https://doi.org/10.1007/BF00309766