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Erhöhte Belastbarkeit der Säuglingsmaus gegen die Infektion mit Variolavirus nach aktiver Immunisierung mit Vaccinia

Enhanced resistance of babymice to variolavirus after active immunization with vaccinia

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Summary

  1. 1.

    Babymice were actively immunized with vacciniavirus. The resulting resistance to a challenge infection with variolavirus is believed to be based on a specific immunity, because

    1. a)

      immunization with influenzavirus resulted in no protection to a subsequent vacciniavirus infection.

    2. b)

      immunization with vacciniavirus resulted in no protection to a subsequent Aujeszkyvirus infection.

    3. c)

      52% of vaccinia-immunized babymice survived a challenge infection with variolavirus, whereas 95% of non-immunized controls succumbed.

  2. 2.

    The 3 strains of vacciniavirus under test (Elstree, Munich-Bern and Rivers) differed in their virulence for babymice. Strain Elstree had the lowest virulence, strain Rivers the highest. Strain Munich-Bern was between the two.

  3. 3.

    The strains Elstree and Munich-Bern rendered almost equal protection to the subsequent variola challenge. The protection afforded by strain Rivers was considerably worse.

Zusammenfassung

  1. 1.

    Die vorgelegten Befunde sprechen dafür, daß bei Säuglingsmäusen durch Vacciniavirus eine spezifische Immunität gegenüber der Infektion mit Variolavirus induzierbar ist.

  2. 2.

    Vacciniavirus der Stämme Elstree, München-Bern und Rivers haben unterschiedliche Pathogenität für die Säuglingsmaus. Stamm Elstree ist am schwächsten pathogen, Stamm Rivers am stärksten. Stamm München-Bern hält die Mitte.

  3. 3.

    Die variola-protektive Wirkung der Stämme Elstree und München-Bern war etwa gleich, die des Stammes Rivers wesentlich schlechter, doch erschwert die unterschiedliche Pathogenität der Vacciniastämme für die Säuglingsmaus die Wertung der Befunde.

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Authors and Affiliations

  1. Bayerische Landesimpfanstalt München und Institut für Vergleichende Tropenmedizin der Universität München, Deutschland

    V. Hochstein-Mintzel, Ch. Epp & A. Herrlich

Authors
  1. V. Hochstein-Mintzel
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  2. Ch. Epp
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  3. A. Herrlich
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Mit Unterstützung der Deutschen Forschungsgemeinschaft.

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Hochstein-Mintzel, V., Epp, C. & Herrlich, A. Erhöhte Belastbarkeit der Säuglingsmaus gegen die Infektion mit Variolavirus nach aktiver Immunisierung mit Vaccinia. Z. med. Mikrobiol. u. Immunol. 154, 160–169 (1968). https://doi.org/10.1007/BF02123704

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  • DOI: https://doi.org/10.1007/BF02123704

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