Abstract
The blast cells of 8 patients with acute lymphatic leukemia were investigated for B- and T-cell properties. Membrane-bound immunoglobulins (B-cell marker) were not found, unexpectedly also not on the blasts of a boy with leukemic transformed lymphosarcoma. In contrast, in another patient, who died shortly after diagnosis, the blasts of different compartments repeatedly showed T-cell properties (spontaneous rosette formation with sheep red blood cells).
Zusammenfassung
Die Blasten von 8 Patienten mit akuter lymphatischer Leukämie wurden auf B- und T-Zell-Eigenschaften untersucht. Membrangebundene Immunglobuline (B-Zell-Marker) wurden dabei nie gefunden, unerwarteterweise auch nicht bei einem Jungen mit leukämisch transformiertem Lymphosarkom. Dagegen zeigten die Blasten bei einem anderen Patienten, der frühzeitig verstarb, in verschiedenen Zellkompartments wiederholt T-Zell-Eigenschaften (Rosettenbildung durch Schafserythrocyten).
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Supported by Deutsche Forschungsgemeinschaft (Schw 187).
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Schwenk, H.U. Immunological cell markers on lymphoblasts of patients with acute lymphatic leukemia. Z. Kinder-Heilk. 118, 87–95 (1974). https://doi.org/10.1007/BF00440024
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DOI: https://doi.org/10.1007/BF00440024