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Primary hypomagnesemia

I. Absorption studies

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Abstract

The clinical course of 2 patients with primary hypomagnesemia is reported. In one male patien, 5 months old, measurements of magnesium retention, intestinal absorption, fecal excretion and renal clearance were performed. The retention (2.8%) and absorption (7.8%) of 28-Mg were markedly reduced in comparison to controls (average retention 25% and average absorption 28%). The retention values of the parents and other relatives did not differ from those of healthy adults. The examined patient was successfully treated with trimagnesium dicitrate containing 1.75 g magnesium per day.

Zusammenfassung

Der klinische Verlauf zweier Patienten mit primärer Hypomagnesämie wird beschrieben. Bei einem Patienten, einem 5 Monate alten Säugling, wurden Magnesiumretention,-resorption,-Stuhlausscheidung und-Clearance gemessen. Die Retention (2,8%) und Resorption (7,8%) von Magnesium28 war deutlich erniedrigt im Vergleich zu Kontrollpersonen, die durchschnittlich 25% retinierten und 28% absorbierten. Zwischen den Retentionswerten der Eltern und Verwandten und denen der gesunden Erwachsenen bestand kein Unterschied. Der untersuchte Patient wurde erfolgreich mit Trimagnesiumdicitrat, entsprechend einer Dosis von 1,75 g Magnesium, behandelt.

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References

  1. Alcock, N., MacIntyre, J.: Interrelation of calcium and magnesium absorption. Biochem. J. 76, 19 (1960)

    Google Scholar 

  2. Bardier, A., Barthe, Ph., Suau, E., Carrière, J.-P., Ribot, C.: A propos d'une observation d'hypocalcémie magnésio-dépendante chez un nourrisson. Arch. franç. Pédiat. 27, 879 (1970)

    Google Scholar 

  3. Cook, D. A.: Availability of magnesium: Balance studies in rats with various inorganic magnesium salts. J. Nutr. 103, 1365 (1973)

    Google Scholar 

  4. Fitzgerald, M. G., Fourman, P.: An experimental study of magnesium deficiency in man. Clin. Sci. 15, 635 (1956)

    Google Scholar 

  5. Friedman, M., Hatcher, G., Watson, L.: Primary hypomagnesemia with secondary hypocalcemia in an infant. Lancet 1967 I, 703

  6. Graham, L. A., Caesar, J. J., Burgen, A. S. V.: Gastrointestinal adsorption and excretion of Mg28 in man. Metabolism 9, 646 (1960)

    Google Scholar 

  7. Hoobler, S. W., Kruse, H. D., McCollum, E. V.: Studies on magnesium deficiency in animals. VIII. The effect of magnesium deprivation on the total and ultrafiltrable calcium and magnesium of the serum. Amer. J. Hyg. 25, 86 (1937)

    Google Scholar 

  8. Keynes, W. M., Barnes, B. A., Cope, O.: Urinary excretion of calcium and magnesium in man using diet with a very low content of these minerals. Proc. roy. Soc. Med. 64, 152 (1971)

    Google Scholar 

  9. Krohn, H.-P., Brodehl, J., Offner, G. Liappis, N., Weber, H. P.: Über die Veränderungen der Nierenfunktion bei der Vitamin D-Mangelrachitis. Mschr. Kinderheilk. 121, 327 (1973)

    Google Scholar 

  10. Liappis, N., Brodehl, J., Dotchev, D., Jäckel, A.: Atomabsorptionsspektrophotometrische Bestimmung der Magnesium-Konzentration im Blutserum von Säuglingen und Kindern. Klin. Wschr. 50, 661 (1972)

    Google Scholar 

  11. Lukács, V. F.: Neonatal transitory hypomagnesemia. Acta paediat. Acad. Sci. hung. 13, 341 (1972)

    Google Scholar 

  12. McIntyre, I., Davidson, D.: The production of secondary potassium depletion, sodium retention, nephrocalcinosis and hypercalcaemia by magnesium deficiency. Biochem. J. 70, 456 (1958)

    Google Scholar 

  13. Miller, E. R., Ullrey, D. E., Zutaut, C. L., Baltzer, B. V., Schmidt, D. A., Hoefer, J. A., Luecke, R. W.: Magnesium requirement of the baby pig. J. Nutr. 85, 13 (1965)

    Google Scholar 

  14. Nordio, S., Donath, A., Macagno, F., Gatti, R.: Chronic hypomagnesemia with magnesium-dependent hypocalcemia. I. A new syndrome with intestinal magnesium malabsorption. Acta paediat. scand. 60, 441 (1971)

    Google Scholar 

  15. Nordio, S., Donath, A., Macagno, F., Gatti, R.: Chronic hypomagnesemia with magnesium-dependent hypocalcemia. II. A study of the relationship between magnesium, calcium and strontium. Acta paediat. scand. 60, 449 (1971)

    Google Scholar 

  16. Paunier, L., Radde, I. C., Kooh, S. W., Fraser, D.: Primary hypomagnesemia with secondary hypocalcemia. J. Pediat. 67, 945 (1965)

    Google Scholar 

  17. Paunier, L., Radde, I. C., Kooh, S. W., Conen, P. E., Fraser, D.: Primary hypomagnesemia with secondary hypocalcemia in an infant. Pediatrics 41 385 (1968)

    Google Scholar 

  18. Paunier, L., Borgeaud, M., Wyss, M.: Urinary excretion of magnesium and calcium in normal children. Helv. paediat. Acta 6, 577 (1970)

    Google Scholar 

  19. Pouillaude, J.-M., Frederich, A., Francois, B., Racle, P., Pernod, J., Francois, R.: Hypomagnésémie congénitale primitive et chronique avec hypocalcémie magnésio-dépendante. Arch. franç. Pédiat. 28, 1021 (1971)

    Google Scholar 

  20. Salet, J., Polonowski, Cl., de Gouyon, F., Pean, G., Melekian, B., Fournet, J.-P., Aymard, P., Raynaud, Cl., Vincent, J.: Tétanie hypocalcémique récidivante par hypomagnésémie congénitale. Arch. franç. Pédiat. 23, 1 (1966)

    Google Scholar 

  21. Salet, J., Polonovski, Cl., Fournet, J.-P., de Gouyon, F., Aymard, P., Pean, G., Taillemite, J.-L.: Démonstration de la nature familiale de l'hypomagnésémie congénitale chronique. Arch. franç. Pédiat. 27, 550 (1970)

    Google Scholar 

  22. Salet, J., Fournet, J.-P.: Les hypomagnésémies de l'enfant (en dehors de la période néo-natale). Ann. Pédiat. 18, 39 (1971)

    Google Scholar 

  23. Schnippering, H. G.: Ein Gesamtkörper-Radioaktivitätszähler zum vielseitigen Einsatz in klinischer Diagnostik und Forschung. Kerntechnik 13, 297 (1971)

    Google Scholar 

  24. Shils, M. E.: Experimental human magnesium depletion. I. Clinical observations and blood chemistry alterations. Amer. J. clin. Nutr. 15, 133 (1964)

    Google Scholar 

  25. Skyberg, D., Strømme, J. H., Nesbakken, R., Harnaes, K.: Neonatal hypomagnesemia with selective malabsorption of magnesium — a clinical entity. Scand. J. clin. Lab. Invest. 21, 356 (1968)

    Google Scholar 

  26. Strømme, J. H., Nesbakken, R., Norman, Tr., Skjørten, F., Skyberg, D., Johannessen, B.: Familial hypomagnesemia. Biochemical, histological and hereditary aspects studied in two brothers. Acta paediat. scand. 58, 433 (1969)

    Google Scholar 

  27. Smith, R. H.: Importance of magnesium in the control of plasma calcium in the calf. Nature (Lond.) 191, 181 (1961)

    Google Scholar 

  28. Vainsel, M., Vandevelde, G., Smulders, J., Vosters, M., Hubain, P., Loeb, H.: Tetany due to hypomagnesemia with secondary hypocalcemia. Arch. Dis. Childh. 45, 254 (1970)

    Google Scholar 

  29. Whang, R., Welt, L. G.: Observations in experimental magnesium depletion. J. clin. Invest. 42, 305 (1963)

    Google Scholar 

  30. Choné, B., Jahns, E. Misri, H. D.: Experimentelle 28-Mg-Verteilungsstudien im Ganzkörperzähler. Nuclearmedizin 7/2, 107 (1968)

    Google Scholar 

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Authors and Affiliations

  1. Kinderklinik III, Universitäts-Kinderklinik, Düsseldorf

    Ingrid Lombeck & H. J. Bremer

  2. Institut für Medizin, Kernforschungsanlage Jülich GmbH, Jülich

    F. Ritzl, H. G. Schnippering & L. E. Feinendegen

  3. Institut für Nuklearchemie, Kernforschungsanlage Jülich GmbH, Jülich

    H. Michael

  4. Kinderklinik der Städtischen Krankenanstalten, Krefeld

    W. Kosenow

Authors
  1. Ingrid Lombeck
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  2. F. Ritzl
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  3. H. G. Schnippering
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  4. H. Michael
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  5. H. J. Bremer
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  6. L. E. Feinendegen
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  7. W. Kosenow
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Additional information

Some parts of the investigations have been supported by the “Landesamt für Forschung des Ministeriums für Wissenschaft und Forschung des Landes Nordrhein-Westfalen”

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Lombeck, I., Ritzl, F., Schnippering, H.G. et al. Primary hypomagnesemia. Z. Kinder-Heilk. 118, 249–258 (1975). https://doi.org/10.1007/BF00492330

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  • DOI: https://doi.org/10.1007/BF00492330

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