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Vitamin A, Carotin, retinolbindendes Protein und Präalbumin im Serum von Patienten mit cystischer Fibrose

Serum concentrations of vitamin A, carotene, retinol-binding protein and prealbumin in patients with cystic fibrosis

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Abstract

Vitamin A, carotene, retinol-binding protein (RBP), and prealbumin (PA) have been measured in 42 children and adolescents with cystic fibrosis (CF) and in 92 normal controls. All patients with CF were on vitamin A palmitate in twice the dose for normals. For statistical analysis U-test of Wilcoxon, Mann and Whitney, parametric correlation coefficient and Spearman's rank correlation coefficient were used. Compared with those in normal controls mean serum concentrations of vitamin A, carotene and RBP were depressed in patients with CF (P<0.001), whereas PA levels did not differ significantly from those of normal individuals. In normal controls there was only in serum concentration of PA an elevation with age (r=0.455, P<0.001). In patients with CF, serum concentration of vitamin A decreased in correlation with age (r=−0.423,P<0.01). PA and RBP as well as RBP and vitamin A were positively related in both groups (P<0.001). In normal individuals there was a highly significant correlation between serum concentrations of vitamin A and carotene (r s=0.606, P<0.001), whereas in patients with CF this relationship was less significant (r s=0.311, P<0.02).

Zusammenfassung

Bei 42 Patienten mit cystischer Fibrose (CF) und bei 92 Normalpersonen wurden die Serumkonzentrationen von Vitamin A, Carotin, retinolbindendem Protein (RBP) und Präalbumin (PA) bestimmt. Alle Patienten mit CF erhielten Vitamin A-Palmitat in Form eines Multivitaminpräparates in der doppelten empfohlenen Dosis für Gesunde. Bei der statistischen Prüfung waren die Serumkonzentrationen von Vitamin A, Carotin und RBP bei den Patienten mit CF im Vergleich zu den Normalpersonen erniedrigt (P<0,001). Für das PA ließ sich zwischen beiden Gruppen ein statistisch signifikanter Unterschied nicht sichern. Bei den Normalpersonen fand sich nur für das PA ein altersabhängiger Anstieg (r=0,455, P<0,001). Bei den Patienten mit CF nahmen die Serumkonzentrationen von Vitamin A in Korrelation zum Lebensalter ab (r=−0,423, P<0,01). PA und RBP sowie RBP und Vitamin A waren bei beiden Gruppen signifikant gleichsinnig korreliert (P<0,001). Bei den Normalpersonen ergab sich auch zwischen Vitamin A und Carotin eine positive Korrelation (r s=0,606, P<0.001), während bei den Patienten mit CF diese Beziehung schwächer signifikant war (r s=0,311, P<0,02).

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Authors and Affiliations

  1. Universitäts-Kinderklinik Bonn, Bonn, Deutschland

    G. Knöpfle, H. W. Rotthauwe & A. Odenthal

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  1. G. Knöpfle
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  2. H. W. Rotthauwe
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  3. A. Odenthal
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Knöpfle, G., Rotthauwe, H.W. & Odenthal, A. Vitamin A, Carotin, retinolbindendes Protein und Präalbumin im Serum von Patienten mit cystischer Fibrose. Z. Kinder-Heilk. 119, 279–291 (1975). https://doi.org/10.1007/BF00443512

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