Abstract
We report on cytogenetic studies of a malformed fetus, whose clinical symptoms indicated the diagnosis of triploidy. This was confirmed by chromosome analysis of peripheral lymphocytes of cord blood. Using the C-banding method it was possible to identify the origin of the extra haploid set: marker chromosomes indicate, that nonreduction of the first meiotic division in the father's spermiogenesis most probably leads, to triploidy. However, in our case fertilization of the zygote by two sperms cannot be excluded.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boué, J., Boué, A., Lazar, P.: Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions. Teratology 12, 1, 11–26 (1975)
Dewald, G., Alvarez, M. N., Cloutier, M. D., Kelalis, P. P., Gordon, H.: A diploid-triploid human mosaic with cytogenetic evidence of double fertilization. Clin. Genet. 8, 149–160 (1975)
Jonasson, J., Therkelsen, A. J., Lauritsen, J. G., Lindsten, J.: Origin of triploidy in human abortuses. Hereditas (Lund) 71, 168–171 (1972)
Niebuhr, E.: Triploidy in man. cytogenetical and clinical aspects. Humangenetik 21, 103–125 (1974)
Niikawa, N., Kajii, T.: A triploid human abortus due to dispermy. Humangenetik 24, 261–264 (1974)
Sumner, A. T.: A simple technique for demonstrating centromere heterochromatin. Exp. Cell Res. 75, 304–306 (1972)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kunze, J., Oldigs, H.D. & Tolksdorf, M. Identification of the triploid genome by the C-banding method. Eur J Pediatr 123, 111–114 (1976). https://doi.org/10.1007/BF00442640
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00442640