Abstract
Serum zinc concentrations in subjects of different ages were estimated by neutron activation analysis to obtain reliable reference values for the diagnosis of primary or secondary zinc deficiency during childhood. In these healthy individuals a small age-dependent variation of the mean values was found. Serum zinc concentrations were lower in cord blood (mean value: 880×10−9 g/ml) and in infants (mean value: 820×10−9 g/ml) than in adults (mean value 1178×10−9 g/ml). In comparison to these values, the serum zinc concentration in a patient with secondary zinc deficiency and 4 patients with acrodermatitis enteropathica was reduced to about 25% of normal.
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Behne, P., Diel, F.: IAEA Symp. on nuclear activation techniques in the life sciences. IAEA-SM 157, 11 (1972)
Berfenstam, R.: Studies on blood zinc. Acta paediat. Suppl. 41, 389 (1952)
Halsted, J. A., Smith, J. C.: Plasma zinc in health and disease. Lancet 1970I, 322
Kasperek, K.: Analytical techniques for the determination of 20 trace elements in biological samples by means of instrumental thermal neutron activation analysis. In: Proc. of the 2nd internat. conf. on nuclear methods in environmental research, U.S. Energy research and development administration, Conf. 740, 701 (1974)
Keilin, D., Mann, T.: Carbonic anhydrase. Purification and nature of the enzyme. Nature 144, 442 (1940)
Lombeck, I., Kasparek, K., Feinendegen, L. E., Bremer, H. J.: Spurenelementkonzentrationen im Serum von Kindern mit Stoffwechselanomalien. In: Vernachlässigte Elemente in der Säuglingsernährung (eds. K. Betke, F. Bidlingmaier), pp. 149–156. München-Berlin-Wien: Urban und Schwarzenberg 1975
MacMahon, R. A., Parker, M., McKinnon, M. C.: Zinc treatment in malabsorption. Med. J. Aust. 2, 210 (1968)
Moynahan, E. J.: Acrodermatitis enteropathica: A letal inherited human zinc-deficiency disorder. Lancet 1974II, 399
Neldner, K. H., Hambidge, K. M.: Zinc therapy of acrodermatitis enteropathica. N. Engl. J. Med. 292, 879 (1975)
Niedermeyer, E., Griggs, J. H.: Trace metal composition of synovial fluid and serum of patients with rheumatoid arthritis. J. chron. Dis. 23, 527 (1971)
Parisi, A. F., Villee, B. L.: Zinc metalloenzymes: Characteristics and significance in biology and medicine. Amer. J. Clin. Nutr. 22, 1222 (1969)
Persigehl, M., Höck, A., Kasparek, K., Land, E., Feinendegen, L. E.: Änderungen der Zinkkonzentration im Serum bei verschiedenen Stoffwechselsituationen. Z. Klin. Chem. Klin. Biochem. 12, 171 (1974)
Prasad, A. S., Halsted, J. A., Nadimi, M.: Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Amer. J. Med. 31, 532 (1961)
Prasad, A. S., Miale, A., Farid, Z., Sandstead, H. H., Schulert, A. R.: Zinc metabolism in patients with the syndrome of iron deficiency, anemia, hepatosplenomegaly, dwarfism and hypogonadism. J. Lab. Clin. Med. 61, 537 (1963)
Samsahl, K., Schramel, P., Thieme, R., Close, B. J.: Eine schnelle neutronenaktivierungs-analytische Methode zur Spurenelementanalyse im Serum. Nucl. Med. 11, 79 (1972)
Thyresson, N.: Acrodermatitis enteropathica. Report of a case healed with zinc therapy. Acta Dermatovener. 54, 383 (1974)
Todd, W. R., Elvehjem, C. A., Hart, E. B.: Zinc in the nutrition of the rat. Amer. J. Physiol. 107, 146 (1934)
Tucker, S. B., Schroeter, A. L., Brown, P. W., McCall, J. T.: Acquired zinc deficiency. J. Am. Med. Ass. 235, 2399 (1976)
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Kasperek, K., Feinendegen, L.E., Lombeck, I. et al. Serum zinc concentration during childhood. Eur J Pediatr 126, 199–202 (1977). https://doi.org/10.1007/BF00477045
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DOI: https://doi.org/10.1007/BF00477045