Abstract
Focal and generalized seizures occurred in 4 patients with acute lymphoblastic leukemia and non-Hodgkin-lymphoma. The etiology of the neurological complications could be established by cranial computerized tomography (CT): i.e., 1. localized metastasis with calcification and 2. acute intracerebral hemorrhage during induction therapy in two patients with malignant lymphomas; 3. diffuse cerebral infiltration with blast cells and 4. cerebral atrophy in two children with acute lymphoblastic leukemia who were in relapse.
Accurate diagnosis of cerebral complications in hemoblastoses is essential for appropriate therapy and CT may lead to more effective treatment in patients with lymphoid malignancy and seizures.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aicardi, J., Goutieres, F., Arsenio-Nunes, M. L., Lebon, R.: Acute measles encephalitis in children with immunosuppression. Pediatrics 59, 232–239 (1977)
Bleyer, W. A., Drake, J. C., Chabner, B. C.: Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukemia. N. Engl. J. Med. 289, 770–773 (1973)
Gagliano, R. G., Costanzi, J. J.: Paraplegia following intrathecal methotrexate. Cancer 37, 1663–1668 (1976)
Hendin, B., Devivo, D. C., Torack, R., Lell, M.-E., Ragab, A. H., Vietti, T. J.: Parenchymatous degeneration of the central nervous system in childhood leukemia. Cancer 33, 486–492 (1974)
Huk, W.: Unpublished
Komp, D. M.: Cytocentrifugation in the management of central nervous system leukemia. J. Pediat. 81, 992–993 (1972)
Law, J. P., Dick, F. R., Blom, J., Bergevin, P. R.: Involvement of the central nervous system in Non-Hodgkin's lymphoma. Cancer 36, 225–231 (1975)
McIntosh, S., Klatskin, E., O'Brien, R., Aspnes, G., Kammerer, B., Snead, C., Kalavsky, S., Pearson, M.: Chronic neurologic disturbance in childhood leukemia. Cancer 37, 853–857 (1976)
Meadows, A. T., Evans, A. E.: Effects of chemotherapy on the central nervous system. Cancer 37, 1079–1085 (1976)
Phair, J. P., Anderson, R. E., Namiki, H.: The central nervous system in leukemia. Annales Int. Med. 61, 863–875 (1964)
Pitner, S. E., Johnson, W. W.: Chronic subdural hematoma in childhood acute leukemia. Cancer 32, 185–190 (1973)
Schwenk, H. U., Willital, G.: Früherkennung der leukämischen Transformation maligner Nicht-Hodgkin-Lymphome im Kindesalter. Dtsch. med. Wschr. 101, 450–454 (1976)
Tatersall, M. H. N., Pitman, S. W., Parker, L. M.: Clinical pharmacology of high dose methotrexate (HDMTX) with citrovorin (CF) rescue. Proc. Am. Assoc. Cancer Res. 16, 161 (1975)
Thomson, J. L. G.: The computed axial tomograph in acute herpes simplex encephalitis. Br. J. Radiol. 49, 86–93 (1976)
Weiss, H. D., Walker, M. P., Wiernik, P. H.: Neurotoxicity of commonly used antineoplastic agents. N. Engl. J. Med. 291, 75–81 (1974)
Wollner, N., Burchenal, J. H., Liebermann, P. H., Exelby, P., D'Angio, G., Murphy, M. L.: Non-Hodgkin's lymphoma in children. Cancer 37, 123–134 (1976)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schwenk, H.U., Neuhäuser, G. & Huk, W. Cranial computerized tomography in children with lymphoid malignancy and seizures. Eur J Pediatr 127, 255–262 (1978). https://doi.org/10.1007/BF00493541
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00493541