Abstract
Fifteen serum proteins were estimated by linear immunodiffusion in blood samples from children with acute hepatitis.
Blood was drawn at the beginning of the disease and three weeks later. The results were compared with results obtained from a group of age-matched normal children.
At the beginning of the disease prealbumin and beta-2-glycoprotein I were depressed, whereas alpha-1-acid-glycoprotein, alpha-1-antitrypsin, ceruloplasmin and alpha-2-HS-glycoprotein were found to be elevated.
Alpha-2-macroglobulin, transferrin and beta-lipoprotein showed a significant elevation after three weeks. Beta-1-A/C, IgM and IgG remained elevated during the time of observation.
Albumin, haptoglobin and IgA were similar in patients and controls and did not change during the period of observation.
Similar content being viewed by others
References
Becker, W., Rapp, W., Schwick, H. G., Störiko, K.: Methoden zur quantitativen Bestimmung von Plasmaproteinen durch Immunpräcipitation. Z. klin. Chem. 6, 113 (1968)
Fateh-Moghadem, A., Lamerz, R., Eisenburg, J., Knedel, M.: Die Bedeutung der Immunglobuline für die Diagnose und Verlaufsbeurteilung von Lebererkrankungen. Klin. Wschr. 47, 129 (1969)
Geiger, H., Hoffmann, P.: Quantitative immunologische Bestimmung von 16 verschiedenen Serumproteinen bei 260 normalen, 0–15 Jahre alten Kindern. Z. Kinderheilk. 109, 22 (1970)
Gleichmann, E., Deicher, H.: Differenzierung der Hypergamma-Globulinämie bei entzündlichen Lebererkrankungen. Klin. Wschr. 45, 684 (1967)
Hitzig, W. H.: Plasmaproteine, Pathophysiologie und Klinik. 2. Auflage. Berlin-Heidelberg-New York: Springer 1977
Kindmark, C. O., Laurell, C. B.: Sequential changes of the plasma protein pattern in inoculation hepatitis. Scand. J. clin. Lab. Invest. 29 suppl. 124, 105 (1972)
Prandota, A., Rudkowski, Z.: Präalbumin als Indikator akuter Hepatitisstadien bei Kindern. Die Gelben Hefte XIV, 77 (1974)
Reis, H. E., Bertrams, J., Selmair, H., Wiese, W., Kuwert, E., Hirche, H.: Immunglobuline und Australia-Antigen bei verschiedenen Formen der Hepatitis und bei Leberzirrhose. Med. Welt 25, 1277 (1974)
Schumacher, K., Maerker-Alzer, G.: Verhalten und Bedeutung der Immunglobuline bei der akuten und chronischen Hepatitis. Internist 14, 578 (1973)
Skrede, S., Blonhoff, J. P., Elgjo, K., Gjone, E.: Serum proteins in diseases of the liver. J. clin. Lab. Invest. 35, 399 (1975)
Wollheim, F. A.: Immunoglobulins in the course of viral hepatitis and in cholestatic and obstructive jaundice. Acta med. scand. 183, 473 (1968)
Zöllner, H., Reddemann, H., Giebelmann, R.: Beziehungen zwischen Haptoglobin und Serumbilirubin bei akuter Hepatitis epidemica im Kindesalter. Dtsch. med. Wschr. 94, 270 (1969)
Author information
Authors and Affiliations
Additional information
Dedicated to Prof. Dr. H. Bickel on the occasion of his 60th birthday
Supported by Deutsche Forschungsgemeinschaft
Rights and permissions
About this article
Cite this article
Moser, C., Geiger, H. & Feist, D. Quantitative determination of single serum proteins during acute hepatitis in childhood. Eur J Pediatr 128, 123–128 (1978). https://doi.org/10.1007/BF00496997
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00496997