Abstract
Two girls aged 6 and 10 years treated with anticonvulsants developed nystagmus and ataxia. The peak plasma concentrations of phenytoin were 42.6 and 46.6 μg/ml, respectively, compatible with phenytoin toxicity. The decline in plasma phenytoin levels did not fit first order kinetics, but followed Michaelis-Menten kinetics.
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Abe, K., Okano, M. & Sasaki, H. Phenytoin elimination kinetics in two children with drug intoxication. Eur J Pediatr 135, 69–71 (1980). https://doi.org/10.1007/BF00445896
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DOI: https://doi.org/10.1007/BF00445896