Skip to main content
SpringerLink
Log in

Serum 25 (OH) D and 24,25 (OH)2 D levels in childhood nephrosis under different therapeutic regimens of steroid administration

  • Original Investigations
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

The effect of prednisone therapy on serum levels of 25-hydroxyvitamin D [25(OH)D] and 24,25-dihydroxyvitamin D [24,25(OH)2D] was investigated in 16 children with nephrotic syndrome. These serum levels were significantly lower in patients before prednisone therapy than in age- and seasonmatched normal subjects. Patients receiving daily prednisone therapy had lower serum levels than those receiving alternateday prednisone therapy at the time when the total amounts of the steroid administered attained 1,500 or 2,000 mg/m2 of body surface area. Daily doses of 40 mg/m2 of prednisone for 3 days caused a significant decrease in serum 25(OH)D levels. Withdrawal of the steroid for 4 consecutive days was followed by a significant recovery of the serum levels.

These results suggest that alternate-day prednisone therapy rather than daily treatment should be used in clinical practice to help maintain normal vitamin D metabolism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

25(OH)D:

25-hydroxyvitamin D

24,25(OH)2D:

24,25-dihydroxyvitamin D

References

  1. Barragry JM, Frace MW, Carter ND, Auton JA, Beer M, Boucher BJ, Cohen RD (1977) Vitamin D metabolism in nephrotic syndrome. Lancet II:629–632

    Article  Google Scholar 

  2. Caldas AE, Gray RW, Lemann JL Jr (1978) The simultaneous measurement of vitamin D metabolites in plasma studies in healthy adults and in patients with calcium nephrolithiasis. J Lab Clin Med 91:840–849

    CAS  PubMed  Google Scholar 

  3. Canterbury JM, Lerman S, Claflin AJ, Henry H Norman A, Reiss E (1978) Inhibition of parathyroid hormone secretion by 25-hydroxycholecalciferol and 24,25-dihydroxycholecalciferol in the dog. J Clin Invest 61:1375–1383

    Article  CAS  Google Scholar 

  4. Chesney RW, Mazess RB, Hamstra AJ, DeLuca HF, O'Reagan S (1978) Reduction of serum-1,25-dihydroxyvitamin D in children receiving glucocorticoids. Lancet II:1123–1125

    Article  Google Scholar 

  5. Fucik RF, Kukreja SC, Hargis GK, Bowser EN, Henderson WJ, Williams GA (1975) Effect of glucocorticoids on function of the parathyroid glands in man. J Clin Endocrinol Metab 40:152–155

    Article  CAS  Google Scholar 

  6. Goldstein DA, Oda Y, Kurokawa K, Massry SG (1977) Blood levels of 25-hydroxyvitamin D in nephrotic syndrome. Ann Intern Med 87:664–667

    Article  CAS  Google Scholar 

  7. Hahn TJ, Halstead LR, Haddad JG Jr (1977) Serum 25-hydroxyvitamin D concentrations in patients receiving chronic corticosteroid therapy. J Lab Clin Med 90:399–404

    CAS  PubMed  Google Scholar 

  8. Hahn TJ, Halstead LR, Baran DT (1981) Effects of short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J Clin Endocrinol Metab 52:111–115

    Article  CAS  Google Scholar 

  9. Henry HL, Norman AW (1978) Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability. Science 201:835–837

    Article  CAS  Google Scholar 

  10. Jowsey J, Riggs BL (1970) Bone formation in hypercortisonism. Acta Endocrinol 63:21–28

    Article  CAS  Google Scholar 

  11. Kanis JA, Cundy T, Bartlet M, Smith R, Heynen G, Warner GT, Russell RG (1978) Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man? Br Med J I:1382–1386

    Article  Google Scholar 

  12. Kano K, Yoshida H, Yata J, Abe E, Tanabe R, Suda T (1979) An assay method for separately measuring metabolites of vitamin D3 and those presumed to be derived from vitamin D2. J Nutr Sci Vitaminol 25:351–360

    Article  CAS  Google Scholar 

  13. Kano K, Yoshida H, Yata J, Suda T (1980) Age and seasonal variations in the serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in normal humans. Endocrinol Jpn 27: 215–221

    Article  CAS  Google Scholar 

  14. Kano K, Nonoda A, Yoneshima H, Suda T (1980) Serum concentrations of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in patients with various types of renal disease. Clin Nephrol 14: 274–279

    CAS  PubMed  Google Scholar 

  15. Klein RG, Arnaud SB, Gallagher JC, DeLuca HF, Riggs BL (1977) Intestinal calcium absorption in exogenous hypercortisonism. J Clin Invest 60:253–259

    Article  CAS  Google Scholar 

  16. Lukert BP, Adams JS (1976) Calcium and phosphorus homeo-stasis in man. Arch Intern Med 136:1249–1253

    Article  CAS  Google Scholar 

  17. Melby JC (1974) Systemic corticosteroid therapy: Pharmacology and endocrinologic considerations. Ann Intern Med 81:505–512

    Article  CAS  Google Scholar 

  18. Mitchell I, Barr OGD, Pocock SJ (1978) Catch-up growth in cortisone-treated rats: Effects of calcium and vitamin D. Pediat Res 12:1105–1111

    Article  CAS  Google Scholar 

  19. Ornoy A, Goodwin D, Noff D, Edelstein S (1978) 24,25-dihydroxyvitamin D is a metabolite of vitamin D essential for bone formation. Nature 276:517–519

    Article  CAS  Google Scholar 

  20. Sturge RA, Beardwell C, Hartog M, Wright D, Ansell BM (1970) Cortisol and growth hormone secretion in relation to linear growth: Patients with Still's disease on different therapeutic regimens. Br Med J III:547–551

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Tokyo Medical and Dental University School of Medicine, 5-45, Yushima 1-chome Bunkyo-ku, 113, Tokyo, Japan

    K. Kano

  2. Department of Biochemistry, School of Dentistry, Showa University, 1-5-8, Hatanodai Shinagawa-ku, Tokyo, Japan

    T. Suda

Authors
  1. K. Kano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Suda
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kano, K., Suda, T. Serum 25 (OH) D and 24,25 (OH)2 D levels in childhood nephrosis under different therapeutic regimens of steroid administration. Eur J Pediatr 138, 162–165 (1982). https://doi.org/10.1007/BF00441145

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00441145

Key words

Search

Navigation