Abstract
Pituitary hyperplasia, microadenoma or an empty sella was detected in three children with primary hypothyroidism and three with Turner syndrome with the use of high resolution contrast-enhanced computed tomography (CT) with thin slices. Hyperplasia or microadenoma of the pituitary gland frequently occurs secondary to primary hypothyroidism and gonadal dysgenesis, and recognition of these results may eliminate unnecessary surgery in favor of hormone replacement therapy. High resolution contrast-enhanced CT, especially coronal CT, with thin slices is very helpful in demonstrating these pituitary abnormalities.
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Danziger J, Wallace S, Handle S, Samaan NB (1979) The sella turcica in primary end organ failure. Neuroradiology 131:111–115
Di Chiro G, Nelson KB (1962) The volume of the sella turcica. Am J Roentgenol 87:989–1008
Furth J, Dent JN, Burnett WT, Gadsden EL (1955) The mechanism of induction and the characteristics of pituitary tumors induced by thyroidectomy. J Clin Endocrinol Metab 15:81–97
Gup RS, Sheeler LR, Maeder MC, Tew JM (1982) Pituitary enlargement and primary hypothyroidism: a report of two cases with sharply contrasting outcomes. Neurosurgery 11:792–794
Haughton VM, Rosenbaum AE, Williams AL, Drayer B (1981) Recognizing the empty sella by CT: The infundibulum sign. Am J Roentgenol 136:293–295
Houssay BA, Houssay AB, Cardez AF (1955) Estrogenic adrenal gland tumours and pituitary tumours in castrated animals. Schweiz Med Wochenschr 85:291–297
Okuno T, Sudo M, Momoi T, Takao T, Ito M, Konishi Y, Yoshida M, Suzuki J, Nakano Y (1980) Pituitary hyperplasia due to hypothyroidism. J Comput Assist Tomogr 4:600–602
Samaan NA, Osborne BM, Mackay B, Leavens ME, Duello TM, Halmi NS (1977) Endocrine and morphologic studies of pituitary adenomas secondary to primary hypothyroidism. J Clin Endocrinol Metab 45:903–911
Samaan NA, Stepanas AV, Danziger J, Trujillo J (1979) Reactive pituitary abnormalities in patients with Klinefelter's and Turner's syndromes. Arch Intern Med 139:198–201
Stockigt JR, Essex WB, West RH, Murray RML, Breidahl HD (1976) Visual failure during replacement therapy in primary hypothyroidism with pituitary enlargement. J Clin Endocrinol Metab 43:1094–1100
Swischuk LE, Sarwar M (1977) The sella in childhood hypothyroidism. Pediatr Radiol 6:1–3
Syversten A, Haughton VM, Williams AL, Cusick JF (1979) The computed tomographic appearance of the normal pituitary gland and pituitary microadenoma. Radiology 133:385–391
Uozumi T, Sakoda K, Ohta M, Iguchi T, Mori S (1983) The image diagnosis of the pituitary adenomas. In: Shizume K, Imura H, Shimizu N (eds) Proceeding of the seventh Asia and Oceania congress of endocrinology. Excerpta Medica, Amsterdam, pp 469–473
Wilkinson IA, Duck SC, Gager WE, Daniels DL (1982) Emptysella syndrome. Am J Dis Child 136:245–247
Yamada T, Tsukui T, Ikejiri K, Yukimura Y, Kotani M (1976) Volume of sella turcica in normal subjects and in patients with primary hypothyroidism and hyperthyroidism. J Clin Endocrinol Metab 42:817–822
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Nishi, Y., Sakano, T., Hyodo, S. et al. Pituitary abnormalities detected by high resolution computed tomography with thin slices in primary hypothyroidism and Turner syndrome. Eur J Pediatr 142, 25–28 (1984). https://doi.org/10.1007/BF00442585
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DOI: https://doi.org/10.1007/BF00442585