Abstract
A successful transplantation of soybean agglutinin (SBA) and sheep red blood cell (SRBC)-fractionated, maternal marrow in a patient with severe combined immunodeficiency (SCID) is reported. The engraftment of HLA-haplotype mismatched marrow cells was obtained without apparent graft versus host disease (GVHD). With immunological reconstituion the patient recovered from a BCG infection, which might have been caused by a BCG inoculation before his bone marrow transplantation.
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Abbreviations
- SCID:
-
severe combined immunodeficiency
- PPD:
-
purimed protein derivative
- SK-SD:
-
streptokinase/streptodornase
- MLC:
-
mixed leukocyte culture
- SBA:
-
soybean agglutinin
- SRBC (E):
-
sheep red blood cell
- GVHD:
-
graft versus host disease
- PHA:
-
phytohaemagglutinin
- Con A:
-
concanavalin A
- PWM:
-
pokeweed mitogen
- EBV:
-
Epstein-Barr virus
- cpm:
-
counts per min
References
Friedrich W, Goldmann SF, Vetter U, Fliedner TM, Heymer B, Peter HH, Reisner Y, Kleinhauer E (1984) Immunoreconstitution in severe combined immunodeficiency after transplantation of HLA-haploidentical, T-cell-depleted bone marrow. Lancet 1:761–764
Masur H, Michelis MA, Greene JB, Onorato I, Stouwe RAV, Holzman RS, Wormser G, Brettman L, Lange M, Muarry HW, Cunningham-Rundles S (1981) An outbreak of community-acquired pneumocystis carinii pneumonia. N Engl J Med 305:1431–1438
Minegishi M, Tsuchiya S, Imaizumi M, Yamaguchi Y, Konno T, Tada K (1984) T-cell subsets analysed by monoclonal antibodies in patients with immunodeficiency diseases. Tohoku J Exp Med 142:231–238
O'Reilly RJ, Kapoor N, Kirkpatrick D, Cunningham-Rundles S, Pollack MS, Dupont B, Hodes MZ, Good RA, Reisner Y (1983) Transplantation for severe combined immunodeficiency using histoincompatible parental marrow fractionated by soybean agglutinin and sheep red blood cells: experience in six consecutive cases. Transplant Proc 15:1431–1435
Prentice HG (1982) OKT3 incubation of donor marrow for prophylaxis of acute graft-vs.-host disease (GVHD) in allogeneic bone marrow transplantation. J Clin Immunol 2:148S-153S
Reinherz EL, Geha R, Rappeport JM, Wilson M, Penta AC, Hussey RE, Fitzgerald KA, Daley JF, Levine H, Rosen FS, Schlossman SF (1982) Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype-mismatched bone marrow for severe combined immunodeficiency. Proc Natl Acad Sci USA 79:6047–6051
Reisner Y, Kapoor N, Kirkpatrick D, Pollack MS, Dupont B, Good RA, O'Reilly RJ (1981) Transplantation for acute leukemia with HLA-A and B nonidentical parental marrow cells fractionated with soybean agglutinin and sheep red blood cells. Lancet 2:327–331
Reisner Y, Kapoor N, Kirkpatrick D, Pollack MS, Cunningham-Rundles S, Dupont B, Hodes MZ, Good RA, O'Reilly RJ (1983) Transplantation for severe combined immunodeficiency with HLA-A, B, D, DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells. Blood 61:341–348
Thomas ED, Storb R, Clift RA, Fefer A, Johnson FL, Neiman PE, Lerner KG, Glucksberg H, Buckner (1975) Bone-marrow transplantation (second of the two parts). N Engl J Med 292:895–902
Touraine JL (1980) Cooperation between thymus and transplanted precursor cells during reconstitution of immunodeficiencies with bone marrow or fetal liver cells. In: Thierfelder S, Rodt H, Kolb HJ (eds) Immunobiology of bone marrow transplantation, Springer, Berlin Heidelberg New York, pp 141–149
Touraine JL, Philippe N, Bétuel H, Souillet G, Bétend B, Souteyrand P, Schmitt D (1981) GVHR and infectious complications in SCID patients treated by bone marrow or fetal liver and thymus transplantation. In: Touraine JL, Gluckman E, Griscelli C (eds) Bone marrow transplantation in Europe II, Excerpta Medica, Amsterdam, pp 209–217
Tsuchiya S, Konno T, Tada K, Ono T (1980) Epstein-Barr virus-induced lymphoblastoid cell lines from patients with primary immunodeficiency diseases. Scand J Immunol 11:155–162
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Minegishi, M., Tsuchiya, S., Imaizumi, M. et al. Successful transplantation of soy bean agglutinin-fractionated, histoincompatible, maternal marrow in a patient with severe combined immunodeficiency and BCG infection. Eur J Pediatr 143, 291–294 (1985). https://doi.org/10.1007/BF00442303
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DOI: https://doi.org/10.1007/BF00442303