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Obstructive endocarditis in an immunodeficient infant

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Abstract

We report the case of 5-week-old male infant who presented as a ‘near miss cot death’. He had the immunodeficient syndrome of defective neutrophil mobility and delayed umbilical cord separation. He was shown to have staphylococcal endocarditis with a large vegetation on the mitral valve, and acute obstruction of the mitral valve flow may have accounted for the suddenness of his presentation. Death resulted from overwhelming sepsis with widely disseminated micro-abscesses.

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References

  1. Beatty PG, Ochs HD, Harlan JM, Price TH, Rosen H, Taylor RF, Hansen JA, Klebanhoff SJ (1984) Absence of monoclonal-antibody-defined protein complex in boy with abnormal leucocyte function. Lancet I:535–537

    Article  Google Scholar 

  2. Bowen RJ, Ochs HD, Altman LC, Price TH, Van Epps DE, Brautigan DL, Rosin RE, Perkins WD, Babior BM, Klepanoff SJ, Wedgwood RJ (1982) Severe recurrent bacterial infections associated ated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein. J Pediatr 101:932–940

    Article  PubMed  CAS  Google Scholar 

  3. Davies EG, Isaacs D, Levinsky RJ (1982) Defective immune interferon production and natural killer activity associated with poor neutrophil mobility and delayed cord separation. Clin Exp Immunol 50:454–460

    PubMed  CAS  Google Scholar 

  4. Hayward AR, Harrey BAM, Leonard J, Greenwood MC, Wood CBS, Soothill JF (1979) Delayed separation of the ummbilical cord, widespread infections, and defective neutrophil mobility. Lancet I:1099–1101

    Article  Google Scholar 

  5. Johnson DH, Rosenthal A, Nadas A (1975) A forty-year review of bacterial endocarditis in infancy and childhood. Circulation 51:581–588

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Intensive Care Unit, The Hospital for Sick Children, Great Ormond Street, WC1N 3JH, London, UK

    M. D. S. Walters, J. E. Deanfield, P. J. Robinson & D. J. Matthew

Authors
  1. M. D. S. Walters
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  2. J. E. Deanfield
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  3. P. J. Robinson
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  4. D. J. Matthew
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Walters, M.D.S., Deanfield, J.E., Robinson, P.J. et al. Obstructive endocarditis in an immunodeficient infant. Eur J Pediatr 145, 553–554 (1986). https://doi.org/10.1007/BF02429063

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  • DOI: https://doi.org/10.1007/BF02429063

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