Abstract
A neonatal case of apo C-II deficiency with hypertriglyceridaemia and xanthomas is presented. The patient responded well to a special diet formula containing medium-chain triglycerides (MCT). This is the first case of apo C-II deficiency to be discovered during the neonatal period.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- EDTA:
-
Ethylenediaminetetraacetic acid
- LPL:
-
Lipoprotein lipase
- MCT:
-
Medium-chain triglyceride
- VLDL:
-
Very low density lipoprotein
References
Breckenridge WC (1986) Apolipoprotein C-II deficiency. In: Angel A, Frohlich J (eds) Advances in experimental medicine and biology, vol 201. Lipoprotein deficiency syndrome. Plenum Press, New York London, pp 211–226
Breckenridge WC, Little JA, Steiner G, Chow A, Poapst M (1978) Hypertriglyceridemia associated with deficiency of apolipoprotein C-II. N Engl J Med 98:1265–1273
Havel RJ, Eder HA, Braydon JH (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins of human serum. J Clin Invest 34:1345–1353
Ishibashi S, Murase T, Takahashi K, Mori N, Kawakami M, Takaku F (1986) Plasma apolipoprotein C-II levels in hypertriglyceridemia. Metabolism 35:781–785
Murase T, Yamada N, Ohsawa N, Kosaka K, Morita S, Yoshida S (1980) Decline of postheparin plasma lipoprotein lipase activity in acromegalic patients. Metabolism 29:666–672
Nikkilä EA (1983) Familial lipoprotein lipase deficiency and related disorders of chylomicron metabolism. In: Stanburg JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. McGraw-Hill, New York, pp 622–642
Sprecher DL, Taam L, Brewer HB (1984) Two-dimensional electrophoresis of human plasma apolipoproteins. Clin Chem 30: 2084–2092
Towbin H, Staehlin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets-procedure and some applications. Proc Natl Acad Sci USA 76:4350–4354
Yamada N, Murase T, Akanuma Y, Itakura S, Kosaka K (1982) Plasma apolipoprotein E levels in hypertriglyceridemia. Horm Metab Res 14:303–306
Yamamura T, Sudo H, Ishikawa K, Yamamoto A (1979) Familial type I hyperlipoproteinemia caused by apolipoprotein C-II deficiency. Atherosclerosis 34:53–65
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ohno, M., Ishibashi, S., Nakao, K. et al. A neonatal case of apolipoprotein C-II deficiency. Eur J Pediatr 148, 550–552 (1989). https://doi.org/10.1007/BF00441556
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00441556