Abstract
Since immunological disorders have been demonstrated in patients with Diamond-Blackfan anaemia (DBA), intravenous immunoglobulins (IVIG) were administered to a 14-year-old girl with DBA and congenital malformations, previously treated with corticosteroids and blood transfusions. No therapeutic effect was observed.
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Abbreviations
- DBA:
-
Diamond-Blackfan anaemia
- hrIL-2:
-
human recombinant interleukin 2
- IVIG:
-
intravenous immunoglobulins
- PBMC:
-
peripheral blood mononuclear cells
References
Clauvel JP, Vainchenker W, Herrera A, Dellagi K, Vinci G, Tabilio A, Lacombe C (1983) Treatment of pure red cell aplasia by high dose intravenous immunoglobulins. Br J Haematol 55:380
Ershler WB, Ross J, Finlay JL, Shahidi NT (1980) Bone marrow microenvironment defect in congenital hypoplastic anaemia. N Engl J Med 302:1321
Nathan DG, Hillmann DG, Chess L, Alter PB, Clarke BJ, Breard J, Housman DE (1978) Normal erythropoietic helper T-cell in congenital hypoplastic anaemia (Diamond-Blackfan syndrome). N Engl J Med 298:1049
Ortega JA, Shore NA, Dukes PP, Hammond D (1975) Congenital hypoplastic anaemia: inhibition of erythropoiesis by sera from patients with CHA. Blood 45:83
Ozsoylu S (1987) High-dose intravenous methylprednisolone for refractory or resistant Diamond-Blackfan anaemia. Eur J Haematol 39:190
Pollak S, Cunningham-Rundles C, Smithwick EM, Barandum S, Good RA (1982) High dose intravenous gammaglobulin for autoimmune neutropenia. N Engl J Med 307:253
Sawada K, Koyanagawa Y, Sakurama S, Nakagawa S, Konno T (1985) Diamond-Blackfan syndrome: a possible role of cellular factors for erythropoietic suppression. Scand J Haematol 35:158
Seip M, Zanussi GF (1988) Cyclosporine in steroid-resistant Diamond-Blackfan anaemia. Acta Pediatr Scand 77:464
Steinberg MH, Coleman MF, Pennebaker JB (1979) Diamond-Blackfan syndrome: evidence for T-cell mediated suppression of erythroid development and a serum blocking factor associated with remission. Br J Haematol 41:57
Viskochil DH, Carey JC, Glader BE, Rothstein G, Christenseen RD (1989) Characterization of the erythropoietic defect in the largest known kindred of congenital hypoplastic (Diamond-Blackfan) anemia. Pediatr Res 25:158A
Wictor-Jedrejczak, Szczylik C, Pajda Z, Siekierzyuski M, Kausy J, Klos M, Ratajczak MZ, Pejcz J, Jaskulski D, Czornas P (1987) Success of bone marrow transplantation in congenital Diamond-Blackfan anemia: a case report. Eur J Haematol 38: 204
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Sopo, S.M., Pesaresi, M.A., Pastore, M. et al. Intravenous immunoglobulin in Diamond-Blackfan anaemia. Eur J Pediatr 149, 779–780 (1990). https://doi.org/10.1007/BF01957279
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DOI: https://doi.org/10.1007/BF01957279