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Variation of 789-1789-1789-1glycoprotein microheterogeneity in hepatic postresuscitation disease

  • Metabolic Diseases
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Abstract

Microheterogeneity of the glycoprotein α1 has been investigated sequentially by high resolution isoelectric focusing in a child with the proteinase inhibitor MS phenotype after near-drowning A band-splitting with additional cathodal fractions exhibited migration from the most cathodic to the anodic positions of the glycoprotein isoforms in the course of postresuscitation disease. The pattern may reflect the time- and stage-dependent hypoxic and post-hypoxic effects on hepatocellular metabolic zonation.

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Abbreviations

Pi:

proteinase inhibitor

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Authors and Affiliations

  1. Klinik für Pädiatrie, Medizinische Universität zu Lübeck, D-2400, Lübeck, Federal Republic of Germany

    K. Heyne & F. -K. Tegtmeyer

  2. Institut für Anthropologie und Humangenetik, Universität München, D-8000, München, Federal Republic of Germany

    S. Weidinger

Authors
  1. K. Heyne
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  2. F. -K. Tegtmeyer
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  3. S. Weidinger
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Dedicated to Professor H.-R. Wiedemann on the occasion of his 75th birthday

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Heyne, K., Tegtmeyer, F.K. & Weidinger, S. Variation of 789-1789-1789-1glycoprotein microheterogeneity in hepatic postresuscitation disease. Eur J Pediatr 149, 789–791 (1990). https://doi.org/10.1007/BF01957283

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  • DOI: https://doi.org/10.1007/BF01957283

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