Abstract
A recent report demonstrated that t(8;16) (p11;p13) may be linked to acute monocytic leukaemia (AMoL) of differentiated subtype (M5b) with active haemophagocytosis by leukaemic cells. Only two cases of neonatal AMoL with t(8;16)(p11;p13) have been reported; M5b with haemophogocytosis and M5a. We report a case of neonatal AMoL (M5b) with t(8;16)(p11;p13), but haemophagocytosis by the leukaemic cells was not detected.
Similar content being viewed by others
Abbreviations
- AMoL:
-
acute monocytic leukaemia
- ANLL:
-
acute non-lymphocytic leukaemia
- VP-16:
-
etoposide
References
Abe R, Ryan D, Cecalupo A, Cohen H, Sandberg AA (1983) Cytogenetic findings in congenital leukemia: case report and review of the literature: Cancer Genet Cytogenet 9:139–144
Barbata G, Carbone P, Mirto S, Santoro A, Giglio MC, Granata G (1989) Translocation t(8;16) (p11;p13) in acute nonlymphoblastic leukemia (M4) possibly secondary to Hodgkin's disease. Cancer Genet Cytogenet 37:127–131
Becher R, Haas OA, Graeven U, Bettelheim P, Ambros P, Fridrik M, Schaefer UW, Schmidt CG (1988) Translocation t(8;16) in acute monocytic leukemia. Cancer Genet Cytogenet 34:265–271
Berger R, Bernheim A, Sigaux F, Daniel MT, Valensi F, Flandrin G (1982) Acute monocytic leukemia chromosome studies. Leuk Res 6:17–26
Bernstein R, Pinto MR, Spector I, Macdougall LG (1987) A unique 8;16 translocation in two infants with poorly differentiated monoblastic leukemia. Cancer Genet Cytogenet 24:213–220
Brizard A, Guilhot F, Huret JL, Benz-Lemoine E, Tanzer J (1988) The 8p11 anomaly in “monoblastic” leukemia. Leuk Res 12:693–697
Heim S, Avanzi G, Billstrom R, Kristoffersson U, Mandahl N, Bekassy AN, Grawicz S, Wiebe T, Pegoraro L, Falda M, Resegotti L, Mitelman F (1987) A new specific chromosomal rearrangement, t(8;16)(p11;p13), in acute monocytic leukaemia. Br J Haematol 66:323–326
Powell BL, McNay JW, Brown S, Cooper MR, Pettenati MJ (1988) Translocation (8;16) (p11;p13) in patients with acute monocytic leukemias. Cancer Genet Cytogenet 36:109–115
Schouten TJ, Hustinx TWJ, Scheres JMJC, Holland R, Vaan de GAM (1983) Malignant histicytosis. Clinical and cytogenetic studies in a newborn and a child. Cancer 52:1229–1236
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hanada, T., Ono, I., Minosaki, Y. et al. Translocation t(8;16)(p11;p13) in neonatal acute monocytic leukaemia. Eur J Pediatr 150, 323–324 (1991). https://doi.org/10.1007/BF01955931
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01955931