Skip to main content
Log in

Translocation t(8;16)(p11;p13) in neonatal acute monocytic leukaemia

  • Hematology/Oncology
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

A recent report demonstrated that t(8;16) (p11;p13) may be linked to acute monocytic leukaemia (AMoL) of differentiated subtype (M5b) with active haemophagocytosis by leukaemic cells. Only two cases of neonatal AMoL with t(8;16)(p11;p13) have been reported; M5b with haemophogocytosis and M5a. We report a case of neonatal AMoL (M5b) with t(8;16)(p11;p13), but haemophagocytosis by the leukaemic cells was not detected.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

AMoL:

acute monocytic leukaemia

ANLL:

acute non-lymphocytic leukaemia

VP-16:

etoposide

References

  1. Abe R, Ryan D, Cecalupo A, Cohen H, Sandberg AA (1983) Cytogenetic findings in congenital leukemia: case report and review of the literature: Cancer Genet Cytogenet 9:139–144

    Google Scholar 

  2. Barbata G, Carbone P, Mirto S, Santoro A, Giglio MC, Granata G (1989) Translocation t(8;16) (p11;p13) in acute nonlymphoblastic leukemia (M4) possibly secondary to Hodgkin's disease. Cancer Genet Cytogenet 37:127–131

    Google Scholar 

  3. Becher R, Haas OA, Graeven U, Bettelheim P, Ambros P, Fridrik M, Schaefer UW, Schmidt CG (1988) Translocation t(8;16) in acute monocytic leukemia. Cancer Genet Cytogenet 34:265–271

    Google Scholar 

  4. Berger R, Bernheim A, Sigaux F, Daniel MT, Valensi F, Flandrin G (1982) Acute monocytic leukemia chromosome studies. Leuk Res 6:17–26

    Google Scholar 

  5. Bernstein R, Pinto MR, Spector I, Macdougall LG (1987) A unique 8;16 translocation in two infants with poorly differentiated monoblastic leukemia. Cancer Genet Cytogenet 24:213–220

    Google Scholar 

  6. Brizard A, Guilhot F, Huret JL, Benz-Lemoine E, Tanzer J (1988) The 8p11 anomaly in “monoblastic” leukemia. Leuk Res 12:693–697

    Google Scholar 

  7. Heim S, Avanzi G, Billstrom R, Kristoffersson U, Mandahl N, Bekassy AN, Grawicz S, Wiebe T, Pegoraro L, Falda M, Resegotti L, Mitelman F (1987) A new specific chromosomal rearrangement, t(8;16)(p11;p13), in acute monocytic leukaemia. Br J Haematol 66:323–326

    Google Scholar 

  8. Powell BL, McNay JW, Brown S, Cooper MR, Pettenati MJ (1988) Translocation (8;16) (p11;p13) in patients with acute monocytic leukemias. Cancer Genet Cytogenet 36:109–115

    Google Scholar 

  9. Schouten TJ, Hustinx TWJ, Scheres JMJC, Holland R, Vaan de GAM (1983) Malignant histicytosis. Clinical and cytogenetic studies in a newborn and a child. Cancer 52:1229–1236

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hanada, T., Ono, I., Minosaki, Y. et al. Translocation t(8;16)(p11;p13) in neonatal acute monocytic leukaemia. Eur J Pediatr 150, 323–324 (1991). https://doi.org/10.1007/BF01955931

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01955931

Key words

Navigation