Abstract
A 4-year-old girl with a lipid cell tumour of the ovary showed isosexual precocious pseudopuberty. The endocrine activity of the tumour led to elevated plasma levels of dehydroepiandrosterone sulphate, oestradiol, testosterone and androstenedione. After tumour resection the clinical signs of abnormal hormonal stimulation disappeared within 10 months. The girl developed precocious puberty again 2 years later without any sign of relapse. Therapy with luteinizing hormone releasing hormone agonist was effective although premature activation of the hypothalamic-pituitary-gonadal axis could not clearly be demonstrated by hormonal investigations.
Similar content being viewed by others
Abbreviations
- FSH:
-
follicle stimulating hormone
- LH:
-
luteinizing hormone
- LHRH:
-
luteinizing hormone releasing hormone
References
Adeyemi SD, Grange AO, et al (1986) Adrenal rest tumor of the ovary associated with isosexual precocious pseudopuberty and cushingoid features. Eur J Pediatr 145:236–238
Ammann AJ, Kaufmann S, Gilbert A (1967) Virilizing ovarion tumor in a 2.5-year-old girl. J Pediatr 70(5):782–787
Behman RE (1992) Nelson textbook of paediatrics. WB Saunders, Philadelphia
Bonaventura LM, Judd H, Roth LM, Cleary RE (1978) Androgen estrogen, and progestogen production by a lipid cell tumor of the ovary. Am J Obstet Gynecol 131:403–408
Cleveland HR, Kushner DC, et al (1987) Lipoid cell tumor of the ovary: a cause of virilization in girls. Am J Dis Child 141: 716–718
Harris AC, Wakely PE jr, Kaplowitz PB, Lovinger RD (1991) Steroid cell tumor of the ovary in a child. Arch Pathol Lab Med 115(2):150–155
Hayes MC, Scully RE (1987) Ovarian steroid cell tumors (not otherwise specified). A clinicopathological analysis of 63 cases. Am J Surg Pathol 11(11):835–845
Imperato-Mc Ginley J, Peterson RE, et al (1981) Steroid hormone secretion from a virilizing lipoid cell tumor of the ovary. Obstet Gynecol 57:525–531
Ishida T, Okagaki T, et al (1977) Lipid cell tumor of the ovary: An ultrastructural study. Cancer 40:234
Lipsett MB, Kirschner MA, et al (1970) Malignant lipid-cell tumor of the ovary: Clinical, biochemical and etiologic considerations. J Clin Endocrinol 30:336–344
Luder AS, Holland FJ, Costigan DC, Jenner RM, Wielgosz G, Fazekas ATA (1984) Intranasal and subcutaneos treatment central precocious puberty in both sexes with a long-acting analog of luteinizing hormone-releasing hormone. J Clin Endocrinol 58(6):966–972
Prader A, Largo RH, et al (1988) Physical growth of Swiss children from birth to 20 years of age. Helv Pacdiatr Acta [Suppl] 52:124
Scully RE, Mark E, McNeely BU (1982) Case records of the Massachusetts General Hospital N Engl J Med 306:1348–1355
Taylor HB, Norris HJ (1962) Lipid cells tumors of the ovary. Cancer 20:1953–1962
Wheeler MD, Styne DM (1990) Diagnosis and management of precocious puberty. Pediatr Clin North Am 37(6):1255–1272
Zachmann M, Manella B, Kempken B, Knorr-Muerset G, Atares M, Prader A (1984) Ovarian steroidogenesis in an adrenalectomized girl with 21-hydroxylase deficiency. Clin Endocrinol 21:575–582
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dengg, K., Fink, F.M., Heitger, A. et al. Precocious puberty due to a lipid-cell tumour of the ovary. Eur J Pediatr 152, 12–14 (1993). https://doi.org/10.1007/BF02072508
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02072508