Abstract
Malignant thymoma was found in an 8-year-old Japanese boy with growth hormone (GH) deficiency who had received GH therapy for 3 years and 5 months. There may be a possible relationship between the occurrence of malignant thymoma and GH therapy.
Similar content being viewed by others
Abbreviations
- GH:
-
growth hormone
References
Bierich JR, Ramashastry R, Kracht J (1967) Neue Untersuchungen zur Entstehung der Thymushyperplasie. Monatsschr Kinderheilkd 115:310–313
Delemarre-Van de Wall HA, Odink RJH, DeGrauw TJ, De-Waal FC (1988) Leukaemia in patients treated with growth hormone. Lancet I: 1159
Endo M, Kaneko Y, Shikano T, Minami H, Chino J (1988) Possible association of human growth hormone treatment with an occurrence of acute myeloblastic leukaemia with an inversion of chromosome 3 in a child with pituitary dwarfism. Med Pediatr Oncol 16: 45–47
Fisher DA, Job J-C, Preece M, Underwood LE (1988) Leukaemia in patients treated with growth hormone. Lancet I: 1159–1160
Hara T, Komiyama A, Ono H, Akabane T (1989) Acute lymphoblastic leukemia in a patient with pituitary dwarfism under treatment with growth hormone. Acta Paediatr Jpn 31: 73–77
Momoi T, Yamanaka C, Yorifuji T, Sasaki H, Kaji M, Akiyama Y, Inomata Y, Tanaka K, Mikawa H (1989) Wilms tumour in a patient with growth hormone replacement therapy. Eur J Paediatr 149: 159–161
Ogawa M, Mori O, Kajijo T, Tomita H, Yazawa T, Miwa K, Tsukidate K, Ogura M, Ohno R (1988) The occurrence of acute lymphoblastic leukaemia shortly after the cessation of human growth hormone therapy. Jpn J Clin Oncol 18: 255–260
O'Neil JE (1987) Anaplastic astrocytoma associated with human growth hormone administration. J Neurol Neurosurg Psychiatry 50: 1078
Rosai J, Levine GD (1976) Tumors of the thymus. Atlas of tumor pathology, second series, fascicle 13. Armed Forces Institute of Pathology, Washington DC
Sasaki U, Hara M, Watanabe S (1988) Occurrence of acute lymphoblastic leukemia in a boy treated with growth hormone for growth retardation after irradiation to the brain tumour. Jpn J Clin Oncol 18: 81–84
Sorkin E, Pierpaoli W, Fabris N, Bianchi E (1972) Relation of growth hormone to thymus and the immune response. In: Pecile A, Muller EE (eds) Growth and growth hormone. Excerpta Medica, Amsterdam, pp 132–142
Souadjian JV, Enriquez P, Silverstein MN, Repin J-M, Minn R (1974) The spectrum of diseases associated with thymoma. Coincidence or syndrome? Arch Intern Med 134: 374–379
Stahnke N, Zeisel HJ (1989) Growth hormone therapy and leukaemia. Eur J Pediatr 148: 591–596
Talwar GP, Pandian MR, Kumar N, Hanjan SNS, Saxena RK, Krishnaraj R, Gupta SL (1975) Mechanism of action of pituitary growth hormone. Recent Prog Horm Res 31: 141–174
Tsuzaki S, Matsuo M, Osano M (1987) The physical growth of Japanese children from birth to 18 years of age: cross-sectional percentile growth curve for height and weight. Helv Paediatr Acta 42: 111–119
Yamato H, Nagashima S, Ninomiya R, Waku S, Furusawa S, Shishido H (1991) Occurrence of malignant histiocytosis with periodic fever during treatment with human growth hormone. Nippon Mounaikei Gakkai Zasshi 31: 55–63
Wada E, Murata M, Watanabe S (1989) Acute lymphoblastic leukemia following treatment with human growth hormone in a boy with possible preanemic Fanconi's anemia. Jpn J Clin Oncol 19: 36–39
Watanabe S (1989) Growth hormone therapy and leukaemia. Annual research reports (The foundation for Growth Science) 13: 327–337
Watanabe S, Tsunematsu Y, Fujimoto J, Komiyama A (1988) Leukaemia in patients treated with growth hormone. Lancet I: 1159
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hasegawa, T., Hasegawa, Y., Koto, S. et al. Malignant thymoma in a patient with growth hormone deficiency during growth hormone therapy. Eur J Pediatr 152, 802–804 (1993). https://doi.org/10.1007/BF02073374
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02073374