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Aneurysmal dilatation of ductus arteriosus during lipo-prostaglandin E1 therapy for diaphragmatic hernia

  • Cardiology
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Abstract

We report a case of congenital diaphragmatic hernia in which aneurysmal dilatation of ductus arteriosus developed after lipo-prostaglandin E1 (PGE1) therapy for persistent fetal circulation. After surgery Lipo-PGE1 was used at a dosage of 5 ng/kg per minute from days 2–9 during which aneurysmal dilatation (7 mm in diameter) developed and remained thereafter. Ductus arteriosus ligation was then performed. Lipo-PGE1 may promote ductus arteriosus dilatation in cases of persistent fetal circulation.

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Abbreviations

DA:

ductus arteriosus

PDA:

patent ductus arteriosus

PFC:

persistent fetal circulation

PGE1 :

prostaglandin E1

References

  1. Benson LN, Olley PM, Patel RG, Coceani F, Rowe RD (1979) The role of prostaglandin E1 infusion in the management of transposition of the great arteries. Am J Cardiol 44:691–696

    PubMed  Google Scholar 

  2. Coceani F, Olley PM (1973) The response of the ductus arteriosus to prostaglandins. Can J Physiol Pharmacol 51:220–225

    PubMed  Google Scholar 

  3. Gittenberger-de Groot AC, Moulaert AJ, Harinck E, Becker AE (1978) Histopathology of the ductus arteriosus after prostaglandin E1 administration in ductus dependent cardiac anomalies. Br Heart J 40:215–220

    PubMed  Google Scholar 

  4. Gittenberger-de Groot AC, Strengers JLM (1988) Histopathology of the arterial duct (ductus arteriosus) with or without treatment with prostaglandin E1. Int J Cardiol 19:153–166

    PubMed  Google Scholar 

  5. Heyman MA, Rudolph AM (1977) Ductus arteriosus dilatation by prostaglandin E1 in infants with pulmonary atresia. Pediatrics 59:325–329

    PubMed  Google Scholar 

  6. Heyman MA, Berman W Jr, Rudolph AM, Whiteman V (1979) Dilatation of the ductus arteriosus by prostaglandin E1 in aortic arch abnormalities. Circulation 59:169–173

    PubMed  Google Scholar 

  7. Ihara K, Maeda S, Otani M, Sasako Y, Kinoshita M, Nakaba H, et al (1984) A survival case of persistent fetal circulation after the repair of diaphragmatic hernia by ligature of ductus arteriosus. J Jpn Assoc Thorac Surg 32:101–106

    Google Scholar 

  8. Leeman M, Lejeune P, Melot C Naeije R (1988) Pulmonary artery pressure-flow plots in hyperoxic and in hypoxic dogs: effects of prostaglandin E1. Eur Respir J 1:711–715

    PubMed  Google Scholar 

  9. Look JE, Olley PM, Coccani F (1980) Direct pulmonary vascular response to prostaglandin in the newborn lamb. Am J Physiol 238:h631

    PubMed  Google Scholar 

  10. Mizushima Y (1988) Application of lipid microspheres for targeting therapy. J Bioact Compat Polym 3:148–156

    Google Scholar 

  11. Mizushima Y, Hamano T, Yokoyama K (1981) Tissue distribution and antiinflammatory activity of corticosteroids incorporated in lipid emulsion. Ann Rheum Dis 40:350

    PubMed  Google Scholar 

  12. Mizushima Y, Yanagawa A, Hoshi K (1983) Prostaglandin E1 is more effective, when incorporated in lipid microspheres, for treatment of peripheral vascular diseases in man. J Pharm Pharmacol 35:666–667

    PubMed  Google Scholar 

  13. Mizushima I, Shiokawa Y, Homma M, Kawasaki S, Ichikawa Y, Hashimoto H, et al (1987) A multicenter double blind controlled study of lipo-PGE1, PGE1 incorporated in lipid microspheres, in peripheral vascular disease secondary to connective tissue disorders. J Rheumatol 14:97–101

    PubMed  Google Scholar 

  14. Mizushima Y, Hamano T, Hamamoto S, Kiyokawa S, Yanagawa A, Nakura K, et al (1990) Distribution of lipid microspheres incorporating prostaglandin E1 to vascular lesions. Prostaglandins leukotrienes and essential fatty acids. 41:269–272

    Google Scholar 

  15. Morikawa I, Ohno T, Hayakawa H, Yoshino M, Mouri A, Ando T, et al. (1985) Effect of prostaglandin E1 for persistent fetal circulation. Acta Neonat Jpn 21:887–894

    Google Scholar 

  16. Neutze JM, Starling MB, Elliott RB, Barratt-Boyes BG (1977) Palliation of cyanotic congenital heart disease in infancy with E-type prostaglandins. Circulation 55:238–241

    PubMed  Google Scholar 

  17. Otomo S, Mizushima Y, Aihara H, Yokokawa K, Watanabe M, Yanagawa A (1985) Prostaglandin E1 incorporated in lipid microspheres (lipo-PGE1). Drugs Exptl Clin Res 11 (9):627–631

    Google Scholar 

  18. Sim AK, McCraw AP, Cleland ME, Aihara H, Otomo S, Hosoda K (1986) The effect of prostaglandin E1 incorporated in lipid microspheres on thrombus formation and thrombus disaggregation and its potential to target to site of vascular lesions. Arzneimittelforschung/Drug Res 36:1206–1209

    Google Scholar 

  19. Starling MB, Elliott RB (1974) The effect of prostaglandins, prostaglandin inhibitors and oxygen on closure of the ductus arteriosus pulmonary arteries and umbilical vessels in vitro. Prostaglandins 8:187–203

    PubMed  Google Scholar 

  20. Yabek SM, Mann JS (1979) Prostaglandin E1 infusion in the hypoplastic left heart syndrome. Chest 76:330–331

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, Shinshu University, 3-1-1 Asahi, 390, Matsumoto, Japan

    M. Tohyama, A. Baba, T. Tsuno, K. Aonuma & A. Komiyama

Authors
  1. M. Tohyama
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  2. A. Baba
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  3. T. Tsuno
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  4. K. Aonuma
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  5. A. Komiyama
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Tohyama, M., Baba, A., Tsuno, T. et al. Aneurysmal dilatation of ductus arteriosus during lipo-prostaglandin E1 therapy for diaphragmatic hernia. Eur J Pediatr 152, 877–879 (1993). https://doi.org/10.1007/BF01957520

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  • DOI: https://doi.org/10.1007/BF01957520

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