Abstract
We report on a boy with a ring 18 chromosome associated with hypothalamic growth hormone (GH) deficiency. A 12-month trial of GH replacement therapy (0.5 U/kg/week) resulted in a marked growth acceleration. Our findings emphasise the need of evaluating GH secretion in patients with abnormalities of the 18 chromosome.
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Abbreviations
- GH :
-
growth hormone
- GHRH :
-
growth hormone releasing hormone
- SDS :
-
standard deviation score
References
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Meloni, A., Boccone, L., Angius, L. et al. Hypothalamic growth hormone deficiency in a patient with ring chromosome 18. Eur J Pediatr 153, 110–112 (1994). https://doi.org/10.1007/BF01959220
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DOI: https://doi.org/10.1007/BF01959220