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Guillain-Barré syndrome associated with IgM anti-GM1 antibody followingCampylobacter jejuni enteritis

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Abstract

We report a 4-year-old girl diagnosed as having Guillain-Barré syndrome after infection by Penner serotype 19 ofCampylobacter jejuni. The patient had the HLA-B35 antigen. Neurological examination revealed distal-dominant weakness and intact sensation. Serial electrophysiological studies indicated that the predominant process was axonal degeneration involving motor nerves. An enzyme-linked immunosorbent assay revealed the presence of high titres of serum IgM antibodies to gangliosides GM1 and GM2. The IgM auto-antibody titres decreased concurrently with the clinical course of the illness and no switching from IgM to IgG secretion took place.

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Abbreviations

CMAPs :

compound muscle action potentials

GBS :

Guillain-Barré syndrome

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Authors and Affiliations

  1. Department of Paediatrics, School of Medicine, University of Chiba, 1-8-1 Inohana, Chuou-ku, 260, Chiba-shi, Chiba, Japan

    K. Sugita, M. Ishii, J. Takanashi & H. Niimi

  2. Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    N. Yuki

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  1. K. Sugita
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  2. M. Ishii
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  3. J. Takanashi
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  4. H. Niimi
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  5. N. Yuki
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Sugita, K., Ishii, M., Takanashi, J. et al. Guillain-Barré syndrome associated with IgM anti-GM1 antibody followingCampylobacter jejuni enteritis. Eur J Pediatr 153, 181–183 (1994). https://doi.org/10.1007/BF01958981

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  • DOI: https://doi.org/10.1007/BF01958981

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