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Fatty acid composition of plasma lipid classes in healthy subjects from birth to young adulthood

  • Nutrition
  • Original Paper
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Abstract

The fatty acid (FA) composition of plasma phospholipids, triglycerides and cholesterol esters (STE) was determined by high resolution capillary gas-chromatography in 115 apparently healthy subjects from birth to young adulthood. After birth, percentage contributions of linoleic and alpha-linolenic acid increased, whereas long-chain polyunsaturated fatty acids decreased in all FA fractions. No difference in plasma FA composition was seen between groups of children aged 1-<5, 5-<10 and 10-<15 years, except for a decrease of total saturated FA in STE between 1-<5 years (18.5%, wt/wt) and 10-<15 years (14.5%,P<0.005). No difference was observed for the values of boys and girls. The results on plasma lipid FA distribution in children aged 1–15 years may be used as reference values for metabolic and nutritional investigations.

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Abbreviations

FA :

fatty acid

LCP :

long-chain polyunsaturated fatty acid

PL :

phospholipid

STE :

sterol ester

TG :

triglyceride

References

  1. Alling C, Westerberg B (1981) Fatty acid composition of serum lecithin in healthy children. Eur J Pediatr 137: 197–201

    PubMed  Google Scholar 

  2. Ewald U, Gustaffson I-B, Tuvemo T, Vessby B (1982) Fatty acid composition of serum lipids in diabetic children and their matched healthy controls. Upsala J Med Sci 87: 111–117

    PubMed  Google Scholar 

  3. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497–509

    PubMed  Google Scholar 

  4. Fomon SJ (1978) Prevention of atherosclerosis. In: Strong WB (ed) Atherosclerosis: its pediatric aspects. Grune and Stratton, New York, pp 231–250

    Google Scholar 

  5. Holman RT, Smythe L, Johnson S (1979) Effect of sex and age on fatty acid composition of human serum lipids. Am J Clin Nutr 32: 2390–2399

    PubMed  Google Scholar 

  6. Honigmann G, Gnauck G, Briedigkeit W, Singer P, Stolz P, Schliack V (1975) Das Fettsäuremuster der Triglyzeride und Cholesterolester in Serum von stoffwechselgesunden Kindern. Dtsch Gesundh-Wesen 30: 1465–1468

    Google Scholar 

  7. Kannel WB, Dawber TR (1972) Atherosclerosis as a pediatric problem. J Pediatr 80: 544–554

    PubMed  Google Scholar 

  8. Kies C, Lopez-Rico ME, Fox HM, Stanek KM, Chan A (1978) Blood serum lipid patterns of adolescent boys fed corn oil, peanut oil, or sawflower oil. J Food Sci 43: 1293–1296

    Google Scholar 

  9. Knuiman JT, West CE, Hermus RJJ, Hautvast JGAJ (1980) Fatty acid composition of cholesteryl esters in serum in boys from 16 developing and developed countries. Atherosclerosis 37: 617–624

    PubMed  Google Scholar 

  10. Koletzko B (1991) Zufuhr, Stoffwechsel und biologische Wirkungen transisomerer Fettsäuren bei Säuglingen. Die Nahrung-Food 35: 229–283

    Google Scholar 

  11. Koletzko B, Bremer HJ (1989) Fat content and fatty acid composition of infant formulae. Acta Paediatr Scand 78: 513–521

    PubMed  Google Scholar 

  12. Koletzko B, Müller L (1990) Cis-and trans-isomeric fatty acids in plasma lipids of newborn infants and their mothers. Biol Neonate 57: 172–178

    PubMed  Google Scholar 

  13. Koletzko B, Abiodun PO, Laryea MD, Schmid S, Bremer HJ (1986) Comparison of fatty acid composition of plasma lipid fractions in well-nourished Nigerian and German infants and toddlers. J Pediatr Gastroenterol Nutr 5: 581–585

    PubMed  Google Scholar 

  14. Koletzko B, Schmidt E, Bremer HJ, Haug M, Harzer G (1989) Effects of dietary long-chain polyunsaturated fatty acids on the essential fatty acid status of premature infants. Eur J Pediatr 148: 669–675

    Article  PubMed  Google Scholar 

  15. Kupke IR (1984) Die Arteriosklerose als pädiatrisches Problem. Dtsch Artzteblart 81: 2793–2805

    Google Scholar 

  16. Moilanen T, Nikkari T, Viikari J, Akerblom HK, Räsänen L, Ahola M, Dahl M, Lähde P-L, Pesonen E, Pietikäinen M, Suoninen P, Uhari M (1985) Atherosclerosis precursors in Finnish children and adolescents. V. Fatty acid composition of serum cholesteryl esters: regional differences in Finland. Acta Paediatr Scand [Suppl] 318: 111–117

    Google Scholar 

  17. Moilanen T, Räsänen L, Viikari J, Akerblom HK, Ahola M, Uhari M, Pasanen M, Nikkari T (1985) Fatty acid composition of serum cholesteryl esters in 3- to 18-year-old Finnish children and its relation to diet. Am J Clin Nutr 42: 708–713

    PubMed  Google Scholar 

  18. Moilanen T, Solakivi-Jaakola T, Viikari J, Räsänen L, Akerblom HK, Uhari M, Pasanen M, Nikkari T (1986) Fatty acid composition of serum cholesteryl esters in relation to serum lipids and apolipoproteins in 3–18-year-old Finnish children and adolescents. Atherosclerosis 59: 113–119

    PubMed  Google Scholar 

  19. Newman WP, Strong JP (1978) Natural history, geographic pathology, and pediatric aspects of atherosclerosis. In: Strong WB (ed) Atherosclerosis: its pediatric aspects. Grune and Stratton, New York, pp 15–40

    Google Scholar 

  20. Nikkari T, Räsänen L, Viikari J, Akerblom HK, Vuori I, Pyörälä K, Uhari M, Dahl M, Lähde P-L, Pesonen E, Suoninen P (1983) Serum fatty acids in 8-year-old Finnish boys: correlations with qualitative dietary data and other serum lipids. Am J Clin Nutr 37: 848–854

    PubMed  Google Scholar 

  21. Ponder DL, Innis SM, Benson JD, Siegman JS (1992) Docosahexaenoic acid status of term infants fed breast milk or infant formula containing soy oil or corn oil. Pediatr Res 32: 683–688

    PubMed  Google Scholar 

  22. Rogiers V (1981) Long chain nonesterified fatty acid patterns in plasma of healthy children and young adults in relation to age and sex. J Lipid Res 22: 1–6

    PubMed  Google Scholar 

  23. Ryan BF, Joiner BL and Ryan TA (1985) Minitab handbook. Boston, PWS-Kent, ed 2

  24. Sanjurjo P, Ojembarrena E, Sasieta M, Lopez Aristegui MA, Samper A (1983) Valores normales de acidos grasos en fracciones lipidicas del plasma en la epoca pediatrica. An Esp Pediatr 19: 347–352

    PubMed  Google Scholar 

  25. Stoffel W, Chu F, Ahrens EH (1959) Analysis of long-chain fatty acids by gas-liquid chromatography. Anal Chem 31: 307–308

    Article  Google Scholar 

  26. Zöllner N, Tato F (1992) Fatty acid composition of the diet: impact on serum lipids and atherosclerosis. Clin Investig 70: 968–1009

    PubMed  Google Scholar 

  27. Zöllner N, Wolfram G, Londong W, Kirsch K (1966) Untersuchungen über die Plasmalipoide des Neugeborenen, Säuglings und Kleinkindes. Klin Wschr 44: 380–386

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Kinderpoliklinik der Ludwig-Maximilians-Universität, Pettenkoferstrasse 8a, D-80336, München, Germany

    B. Koletzko & T. Decsi

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  1. B. Koletzko
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  2. T. Decsi
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Koletzko, B., Decsi, T. Fatty acid composition of plasma lipid classes in healthy subjects from birth to young adulthood. Eur J Pediatr 153, 520–525 (1994). https://doi.org/10.1007/BF01957009

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  • DOI: https://doi.org/10.1007/BF01957009

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