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Complications of childhood Sjögren syndrome

  • Immunology/Allergology
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Abstract

Sjögren syndrome (SS) is a common disorder in adults and involves both glandular and extraglandular systems. We report here four cases of childhood SS complicated by chronic thyroiditis, interstitial nephritis or sweat gland inflammation. Additionally, in one of these cases, the central nervous system was involved. All of these complications are common in adult cases.

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Abbreviations

dRTA :

distal renal tubular acidosis

KCS :

keratoconjunctivitis sicca

PSP :

phenolsulphophthalein

s-GPT :

serum glucose pyruvate transaminase

s-GOT :

serum glutamate oxalate transaminase

SS :

Sjögren syndrome

References

  1. Alexander EL (1986) Central nervous system (CNS) manifestation of primary Sjögren's syndrome; an overview. Scand J Rheumatol [Suppl] 61:161–165

    Google Scholar 

  2. Alexander EL, Ranzenbach MR, Kumar AJ, Kozachuk WE, Rosenbaum AE, Patronas N, Harley, JB Reichlin M (1994) Anti-Ro (SS-A) autoantibodies in central nervous system disease associated with Sjögren's syndrome (CNSSS): clinical, neuroimaging, and angiographic correlates. Neurology 44:899–908

    Google Scholar 

  3. Athreya BH, Norman ME, Myers AR, South MA (1977) Sjögren's syndrome in children. Pediatrics 59:931–938

    Google Scholar 

  4. Bloch KJ, Buchanan WW, Wohl MJ, Bunin JJ (1965) Sjögren's syndrome. A clinical, pathological and serological studies of 62 cases. Medicine 44:187–231

    Google Scholar 

  5. Chudwin DS, Daniels TE, Wara DW, Ammann AJ, Barrett DJ, Whitcher JP, Cowan MJ (1981) Spectrum of Sjögren's syndrome in children. J Pediatr 98:213–217

    Google Scholar 

  6. Deprettere AJ, Van Acker KJ, De Clerck LS, Docx MK, Stevens WJ, Van Bever HP (1988) Diagnosis of Sjögren's syndrome in children. Am J Dis Child 142:1185–1187

    Google Scholar 

  7. Epstein O, Thomas HC, Sherlock S (1980) Primary biliary cirrhosis is a dry gland syndrome with features of chronic graft-versus-host disease Lancet 1:1166–1168

    Google Scholar 

  8. Fox RI, Robinson CA, Curd JG, Kozin F, Howell FV (1986) Sjögren's syndrome; proposed criteria for classification. Arthritis Rheum 29:577–585

    Google Scholar 

  9. Fraga A, Gudiño J, Ramos-Niebro F, Alarcón-Segovia D (1978) Mixed connective tissue disease in childhood. Relationship with Sjögren's syndrome. Am J Dis Child 132:263–265

    Google Scholar 

  10. Franklin DJ, Smith RJH, Person DA, Pflugfelder SC (1986) Sjögren's syndrome in children. Otolaryngol Head Neck Surg 94:230–235

    Google Scholar 

  11. Mizuno Y, Hara T, Hatae K, Hirano T, Ueda K, Nakamura N, Mizoguchi Y (1989) Recurrent parotid gland enlargement as an initial manifestation of Sjö-gren's syndrome in children. Eur J Pediatr 148:414–416

    Google Scholar 

  12. Rosenberg AM, Dyck RF, George DM (1990) Intravenous pulse methylprednisolone for the treatment of a child with Sjögren's nephropathy. J Rheumatol 17:391–394

    Google Scholar 

  13. Shioji R, Furuyama T, Onodera S, Saito H, Ito H, Sasaki Y (1970) Sjögren's syndrome and renal tubular acidosis. Am J Med 48:456–463

    Google Scholar 

  14. Siamopoulou-Mavridou A, Drosos AA, Andropoulos AP (1989) Sjögren's syndrome in childhood; report of two cases. Eur J Pediatr 148:523–524

    Google Scholar 

  15. Talal N, Zisman E, Schur PH (1970) Renal tubular acidosis and immunologic factors in Sjbgren's syndrome. Arthritis Rheum 11:774–786

    Google Scholar 

  16. Talal N, Darphinee MJ, Dang H, Alexander SS, Hart DJ, Garry RF (1990) Detection of serum autoantibodies to retroviral protein in patients with primary Sjögren's syndrome (autoimmune exocrinopathy). Arthritis Rheum 33:774–781

    Google Scholar 

  17. Vermylen C, Meurant A, Claus D, Corms G (1985) Sjögren's syndrome in a child. Eur J Pediatr 144:266–269

    Google Scholar 

  18. Whaley K, Webb J, McAvoy BA, Hughes GRC, Lee P, MacSween RNM, Buchanan WW (1973) Sjögren's syndrome. 2. Clinical associations and immunological phenomena. Quart J Med 42:513–548

    Google Scholar 

  19. Whaley K, Alspaugh M (1985) Sjögren's syndrome. In: Kelley WN, Harris ED, Ruddy S, Sledge CL (eds). Textbook of rheumatology, 2nd edn. Saunders, Philadelphia, pp 956–973

    Google Scholar 

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Kobayashi, I., Furuta, H., Tame, A. et al. Complications of childhood Sjögren syndrome. Eur J Pediatr 155, 890–894 (1996). https://doi.org/10.1007/BF02282840

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  • DOI: https://doi.org/10.1007/BF02282840

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