Abstract
Eight adult, untreated patients with classical phenylketonuria received L-dopa and a decarboxylase inhibitor for 2 weeks. No effect of l-dopa therapy on choice reaction time tasks, sustained attention, frontal lobal function as well as latencies of visual evoked potentials was found. The results raise the question if adult patients with phenylketonuria really suffer from functional dopamine deficiency.
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Abbreviations
- CWIT :
-
Colour Word Interference Task (Stroop)
- Phe :
-
phenylalanine
- SVAT/DPE :
-
Sonneville Visual Attention Task/subtest: Dot Pattern Exercise
- VEP :
-
visual evoked potential
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Ullrich, K., Weglage, J., Pietsch, M. et al. Effect of l-dopa on visual evoked potentials and neuropsychological tests in adult phenylketonuria patients. Eur J Pediatr 155 (Suppl 1), S74–S77 (1996). https://doi.org/10.1007/PL00014256
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DOI: https://doi.org/10.1007/PL00014256