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Induction of tumors of the forestomach in rats by oral application of N-methyl-N′-nitro-nitrosoguanidine

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Summary

After 12 oral applications of 80 mg/kg MNNG as a suspension in 30% aqueous ethanol at weekly intervals, 98 Sprague-Dawley rats died with multiple tumors of the forestomach after a medium latency period of 226 days. Histological examination showed generalized papillomatosis developing into keratinizing squamous cell carcinomas with infiltrative growth in 88/98 (89%) animals. Tumorigenic lesions in the glandular stomach ware only observed in 3/98 rats. In two of these animals, mucosal adenocarcinomas were found and in the third a leiomyosarcoma. In about 30% of the animals treated with MNNG, degenerative liver changes were found, especially single cell and focal necroses, cystic alterations, and bile-duct proliferations.

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Authors and Affiliations

  1. German Cancer Research Center, Institute of Toxicology and Chemotherapy, D-6900, Heidelberg 1, Germany

    G. Eichler, M. Habs & D. Schmähl

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  1. G. Eichler
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  2. M. Habs
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  3. D. Schmähl
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Eichler, G., Habs, M. & Schmähl, D. Induction of tumors of the forestomach in rats by oral application of N-methyl-N′-nitro-nitrosoguanidine. J Cancer Res Clin Oncol 105, 194–196 (1983). https://doi.org/10.1007/BF00406933

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  • DOI: https://doi.org/10.1007/BF00406933

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