Summary
The chemotherapeutic activity of five cytostatic drugs was investigated experimentally in monotherapy and in two-drug combinations, using Yoshida sarcoma cells implanted into the wall of the glandular stomach of Sprague-Dawley rats. In monotherapy, the antibiotic agent mitomycin C and the nitrosourea methyl-CCNU exhibited the highest cytotoxic activity in this tumor model. In combination therapy, the combination of these two drugs was superior to all the other therapeutic schemes tested. In general, the results demonstrate a marked superiority of combination therapy in comparison with monotherapy.
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These studies correspond to the doctoral thesis “Chemotherapeutische Studien an Ratten mit in den Drüsenmagen implantierten Yoshida-Sarkom-Asciteszellen: Monotherapie mit 5-Fluorouracil, Methyl-CCNU, Mitomycin C, Adriamycin und Cytosinarabinosid, Kombinationstherapie mit den Zweierkombinationen dieser Substanzen” submitted to the Medical Faculty of Heidelberg University in 1982 by G. Eichler
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Eichler, G., Habs, M. & Schmähl, D. Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats. J Cancer Res Clin Oncol 105, 250–257 (1983). https://doi.org/10.1007/BF00395753
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DOI: https://doi.org/10.1007/BF00395753