Summary
Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-methylamine (AMMN) which are used worldwide for etiological and therapy studies of colon cancer are compared for tumor biology and clinical relevance. The four tumor models of colon carcinoma described in the rat are different in growth, invasion, and metastases. The choice of the selected tumor model for experimental investigations of colon cancer should depend on the clinical question.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amberger H (1984) Biological behavior of various autochthonous tumor models of colon cancer in the rat. In: Georgii A (ed) Aspects of clinical oncology. Gustav Fischer Verlag, Stuttgart, New York
Druckrey H (1970) Production of colonic carcinomas by 1,2-dialkyl-hydrazines and azoxyalkanes. In: Burdette WJ (ed) Carcinoma of the colon and antecedent epithelium. C.C. Thomas Springfield, O.: 267–269
Habs M, Schmähl D (1978) Experimental testing of chemotherapeutic agents in autochthonous tumors with special reference to colo-rectal cancer. In: Grundmann E (ed) Colon cancer. Gustav Fischer Verlag, Stuttgart, New York
Habs M, Schmähl D, Wiessler M (1978) Carcinogenity of acetoxymethyl-methyl-nitrosamine after subcutaneous intravenous and intrarectal application in rats. Z Krebsforsch 91:217–221
Merz R, Wagner J, Habs M, Amberger H, Bachmann U (1981) Endoscopic evaluation of autochthonous colon carcinoma in rats. Hepatogastroenterology 28:53–57
Narisawa T, Weisburger JH (1975) Colon cancer induction in mice by intrarectal instillation of N-methylnitrosourea. Proc Soc Exp Biol Med 148:166–169
Narisawa T, Sato T, Hayakawa M, Sakuma A, Nakano H (1971) Carcinoma of the colon and rectum of rats by rectal infusion of N-methyl-N-nitro-N-nitrosoguanidine. Gann 62:231–234
Ross JS (1981) Experimental large intestinal adenocarcinoma induced by hydrazines and human colorectal cancer: a comparative study. In: Malt RA, Williamsen RCN (eds) Colonic carcinogenesis. MTP Press Limited, Lancaster, Boston, The Hague
Schmähl D (1976) In: Hellman K, Connors TA (eds) Utilisation of nitrosamine induced tumors as models for cancer chemotherapy. Chemotherapy Vol 7. Plenum Publishers, New York, pp 233–238
Schmähl D (1981) Colon carcinogenesis and co-carcinogenesis. In: Malt RA, Williamson RCN (eds) Colonic carcinogenesis MTP Press Limited, Lancaster, Boston, The Hague
Schmähl D (1981) Entstehung, Wachstum und Chemotherapie maligner Tumoren. 3 ed, Edition Cantor, Aulendorf
Sych F, Habs M, Schmähl D (1978) Chemotherapy studies in autochthonous tumors: Intestinal cancer. Z Krebsforsch 92:105–117
Wiebecke B (1975) Experimentelle Cancerogenese des Darms. In: Grundmann E (ed) Handbuch der allgemeinen Pathologie. III. Geschwülste. Springer, Berlin Heidelberg, New York
Author information
Authors and Affiliations
Additional information
Dedicated to Professor Dietrich Schmähl on the occasion of his 60th birthday
Rights and permissions
About this article
Cite this article
Amberger, H. Different autochthonous models of colorectal cancer in the rat. J Cancer Res Clin Oncol 111, 157–159 (1986). https://doi.org/10.1007/BF00400756
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00400756