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CD7-positive acute myeloid leukemia: further evidence of cellular immaturity

  • Original Papers
  • Clinical Oncology
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Summary

Among 63 cases of acute myeloid leukemia (AML), 14 were found to express the CD7 antigen, a cell surface marker usually found at an early stage during T lineage differentiation. The CD7-positive AML cases consisted of 5 cases of M1, 3 cases of M2, 3 cases of M4, 1 case of M5, 1 case of M6 and 1 case of M7. Among these 63 cases, the proportion of blast cells expressing the CD34 antigen was examined. The proportion of CD34-stained cells among the CD7-positive AML cases, although varying, was significantly larger than that among the CD7-negative AML cases (P<0.05). As the CD34 antigen was expressed on hematopoietic progenitor cells and was considered to reflect an early hematopoietic stage, the high proportion of cells expressing CD34 among the CD7-positive AML cases may support the notion that CD7-positive AML cells are immature.

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Abbreviations

AML:

acute myeloid leukemia

CD:

clusters of differentiation

References

  • Bennett J, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1985) Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Ann Intern Med 103:626–629

    Google Scholar 

  • Bertho JM, Mossalayi MD, Dalloul AH, Mouterde G, Debre P (1990) Isolation of an early T-cell precursor (CFU-TL) from human bone marrow. Blood 75:1064–1068

    Google Scholar 

  • Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH (1984) A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J Immunol 133:157–165

    Google Scholar 

  • Coco FL, Rossi GD, Pasqualetti, Lopoz M, Diverio D, Latagliata R, Fenu S, Mandelli F (1989) CD7 positive acute myeloid leukaemia: a subtype associated with cell immaturity. Br J Haematol 73:480–485

    Google Scholar 

  • Ema H, Suda T, Miura Y, Nakauchi H (1990) Colony formation of clone-sorted human hematopoietic progenitors. Blood 75:1941–1946

    Google Scholar 

  • Haynes BF, Mann DL, Shroer ME, Shelhamer JA, Eisenbarth JH, Strominger JE, Thomas CA, Mostowki HS, Fauci AS (1980) Characterization of a monoclonal antibody that defines an immunoregulatory T-cell subset for immunoglobulin synthesis in humans. Proc Natl Acad Sci USA 77:2914–2918

    Google Scholar 

  • Katz F, Simpson E, Lam G, Gibbons B (1988) Rearrangement of T-cell receptor and immunoglobulin heavy chain genes in childhood acute mixed lineage leukaemia. Leuk Res 12, 956–960

    Google Scholar 

  • Kondo S, Okamura S, Asano Y, Harada M, Niho Y (1991) Human granulocyte colony-stimulating factor receptors in acute myelogenous leukaemia. Eur J Haematol 46:223–230

    Google Scholar 

  • Kurtzberg J, Waldmann TA, Davey MP, Binger SH, Moore JO, Hershfield MS, Haynes BF (1989) CD7+, CD4−, CD8− acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells. Blood 73:381–390

    Google Scholar 

  • Lopez M, Rossi De, Bonomo G, Ranucci A, Guglielmi C, Pasqualetti D, Vitale A, Mandelli F (1985) Relevance of 3A1 monoclonal antibody in the diagnosis of T-cell acute lymphoblastic leukemia. Diagn Immunol 3:11–14

    Google Scholar 

  • Molgaard HV, Spurr NK, Greaves MF (1989) The hemopoietic stem cell antigen, CD34, is encoded by a gene located on chromosome 1. Leukemia 3:773–776

    Google Scholar 

  • Okamura S, Hayashi S, Kawasaki C, Kondo S, Asano S, Omori F, Otsuka T, Shibuya T, Harada M, Niho Y (1989) Expression of cytokine gene in hematological malignancies. Acta Haematol Jpn 52:1423–1432

    Google Scholar 

  • Osada H, Emi N, Ueda R, Seto M, Koike K, Suchi T, Kojima S, Obata Y, Takahashi T (1990) Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma. Leuk Res 14, 869–877

    Google Scholar 

  • Pittaluga S, Raffeld M, Lipford EH, Cossman J (1986) 3A1 (CD7) expression precedes T-cell receptor (TCR) chain gene rearrangements in precursor T (lymphoblastic) neoplasms. Blood 61:134–137

    Google Scholar 

  • Vodinelich L, Tax W, Bai Y, Pegram B, Capel P, Greaves MF (1983) A monoclonal antibody (WT1) for detecting leukemias of T-cell precursors (T-ALL). Blood 62:1108–1113

    Google Scholar 

  • Zutter MM, Martin PJ, Hanke D, Kidd PG (1990) CD7+ acute non-lymphocytic leukemia: evidence for an early multipotential progenitor. Leuk Res 14:23–26

    Google Scholar 

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Authors and Affiliations

  1. The First Department of Medicine, Kyushu University, Fukuoka, Japan

    Seiji Kondo, Mine Harada, Tsunefumi Shibuya, Takashi Okamura, Shigeru Yamaga, Fusayuki Omori & Yoshiyuki Niho

  2. Cancer Center, Faculty of Medicine, Kyushu University Hospital, 5-1-1 Maidashi, Higashi-ku, Fukuoka, Japan

    Seiji Kondo, Seiichi Okamura, Naoki Harada, Wataru Ikematsu, Chiyuki Kawasaki, Takahiro Fukuda, Akira Kubota & Kazuya Shimoda

  3. Sanshinkai-Hara Hospital, Fukuoka, Japan

    Hisashi Gondo & Shin Hayashi

Authors
  1. Seiji Kondo
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  2. Seiichi Okamura
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  3. Naoki Harada
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  4. Wataru Ikematsu
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  5. Chiyuki Kawasaki
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  6. Takahiro Fukuda
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  7. Akira Kubota
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  8. Kazuya Shimoda
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  9. Mine Harada
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  10. Tsunefumi Shibuya
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  11. Takashi Okamura
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  12. Hisashi Gondo
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  13. Shin Hayashi
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  14. Shigeru Yamaga
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  15. Fusayuki Omori
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  16. Yoshiyuki Niho
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Additional information

Partly supported by grants-in-aid from the Ministry of Education, Culture and Science of Japan (03252102, 63015063, 02256102, and 03670325) and from theFukuoka Anti-Cancer Society

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Kondo, S., Okamura, S., Harada, N. et al. CD7-positive acute myeloid leukemia: further evidence of cellular immaturity. J Cancer Res Clin Oncol 118, 386–388 (1992). https://doi.org/10.1007/BF01294444

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  • DOI: https://doi.org/10.1007/BF01294444

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