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Fehlen einer carcinogenen Wirkung von 7-Methylguanin bei Ratten

Lack of carcinogenic action of 7-methylguanine in rats

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Summary

Subcutaneous and intravenous injections of 7-methylguanine (single dose: 1 mg/animal/twice weekly; total dose: 212 mg/animal) showed no carcinogenic action in BR 46 rats. The medium life span of the experimental groups corresponded to that of the controls.

Zusammenfassung

Subcutane und intravenöse Injektionen von 7-Methylguanin (Einzeldosis: 1 mg/Tier/2 x Woche; Gesamtdosis: 212 mg/Tier) wirkten bei BR 46-Ratten nicht cancerogen. Die mittlere Lebenserwartung der Versuchstiere entsprach der der Kontrollen.

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Authors and Affiliations

  1. Institut für exp. Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum Heidelberg, Heidelberg, Deutschland

    F. W. Krüger & D. Schmähl

Authors
  1. F. W. Krüger
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  2. D. Schmähl
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Additional information

Diese Arbeit wurde mit Unterstützung der Deutschen Forschungsgemeinschaft, Bad Godesberg, und des Vereins zur Förderung der Krebsforschung e. V. durchgeführt.

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Krüger, F.W., Schmähl, D. Fehlen einer carcinogenen Wirkung von 7-Methylguanin bei Ratten. Z Krebs-forsch 75, 253–254 (1971). https://doi.org/10.1007/BF00641955

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  • DOI: https://doi.org/10.1007/BF00641955

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