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Antitumor potency of ascorbic, dehydroascorbic or 2, 3-dike-togulonic acid and their action on deoxyribonucleic acid

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Summary

Three nutritively significant enediol compounds mentioned in above title can inhibit sarcoma-180 growth. The inhibition by ascorbic acid is enhanced by cupric ions. These enediols depolymerize DNA, particularly in co-operation with copper. Dehydroascorbic acid is able to break denatured DNA and to bring about single strand scission for native one. A mixture of dehydroascorbate and Cu decomposes apurinic acid and liberates deoxy-cytidylic acid from it. Only the oligo-form pf pyrimidine tetra- and penta-nucleotides is disintegrated by this reagent. The results were briefly discussed in relation to metabolic carcinostasis and to the formulation of Yamafuji effect causing cellular differentiation and anomalization.

Zusammenfassung

Die im obigen Titel erwähnten, drei nutritiv bedeutenden Endiol-Verbindungen können Sarkom-180 hemmen. Die hemmende Wirksamkeit von Ascorbinsäure wird durch Cupri-Ionen verstärkt. Diese Endiolen depolymerisieren DNS, besonders unter Mitwirkung von Kupfer. Dehydroascorbinsäure besitzt die Fähigkeit, denaturierte DNS zu brechen und eine einstrangige Spaltung für native Nucleinsäure zu bewirken. Eine Mischung von Dehydroascorbat und Cu zersetzt Apurinsäure und trennt daraus Deoxy-cyctidylsäure. Nur die Oligo-Form von Pyrimidin-Tetra- und Penta-Nucleotiden wird durch dieses Reagens desintegriert. Die Ergebnisse wurden im Zusammenhang mit der metabolischen Carcinostasis und der Formulierung des cellulären, Differenzierung und Anomalisation verursachenden Yamafuji-Effekts kurz diskutiert.

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Authors and Affiliations

  1. Agricultural Faculty, Food Chemistry Laboratory, Kyushu University, Fukuoka, Japan

    K. Yamafuji, Y. Nakamura, H. Omura, T. Soeda & K. Gyotoku

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  1. K. Yamafuji
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  2. Y. Nakamura
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  3. H. Omura
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  4. T. Soeda
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  5. K. Gyotoku
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Yamafuji, K., Nakamura, Y., Omura, H. et al. Antitumor potency of ascorbic, dehydroascorbic or 2, 3-dike-togulonic acid and their action on deoxyribonucleic acid. Z. Krebsforsch. 76, 1–7 (1971). https://doi.org/10.1007/BF00304282

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  • DOI: https://doi.org/10.1007/BF00304282

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