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Zur carcinogenen Wirkung von N-Nitroso-Verbindungen

7. Mitteilung: Methyl-, Trideuteromethyl-, Äthyl-, n-Propyl-, n-Butyl-, Acetoxymethyl-Nitrosamin und Methyl-Butyroxymethyl-Nitrosamin

On the carcinogenetic action of N-Nitroso compounds. 7th Communication:

Methyl-, trideuteromethyl-, ethyl-, n-propyl-, n-butyl-, acetoxymethyl-nitrosamine, and methyl-butyroxymethyl-nitrosamine

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Summary

The homologons alkyl-acetoxymethyl-nitrosamines were tested for carcinogenicity in SD rats. All compounds were found to be carcinogenic and induced within the same time carcinomas of the forestomach. The total doses necessary for induction of tumors are related to the length of the alkyl chain and hence to the watersolubility. These results are discussed.

Zusammenfassung

Die homologe Reihe der Alkyl-Acetoxymethyl-Nitrosamine wurden auf ihre carcinogene Wirkung an SD Ratten getestet. Alle Verbindungen induzieren bei oraler Gabe innerhalb der gleichen Zeit Vormagentoumoren. Die benötigten Gesamtdosen sind dabei abhängig von der Länge der Alkyl-Kette und damit der Wasserlöslichkeit. Diese Ergebnisse werden diskutiert.

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Authors and Affiliations

  1. Institut für Toxikologie und Chemotherapie am Deutschen Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, Bundesrepublik Deutschland

    M. Wiessler, M. Habs & D. Schmähl

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  1. M. Wiessler
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  2. M. Habs
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  3. D. Schmähl
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Wiessler, M., Habs, M. & Schmähl, D. Zur carcinogenen Wirkung von N-Nitroso-Verbindungen. Z. Krebsforsch. 91, 317–322 (1978). https://doi.org/10.1007/BF00312293

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  • DOI: https://doi.org/10.1007/BF00312293

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