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Chemotherapy studies in autochthonous rat tumors intestinal cancer

Chemotherapeutische Untersuchungen an autochthonen Tumoren der Ratte — Darmkrebs

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Summary

Intestinal tumors in rats were induced by three different chemical carcinogens. Only tumors induced by 1,2-dimethylhydrazine responded slightly to combination chemotherapy of Adriamycin, Methotrexate, 5-Fluorouracil, and Cyclophosphamide. The same therapy failed in tumors induced by N-methyl-N′-nitro-N-nitroso-guanidine or acetoxymethyl-methyl-nitrosamine. These results and the comparability of chemotherapy in autochthonous tumors to experimental and clinical observations are discussed.

Zusammenfassung

Durch drei chemische Carcinogene wurden Darmtumoren bei Ratten induziert. Nur bei durch 1,2-Dimethylhydrazin induzierten Tumoren konnte eine schwache Reaktion auf eine Kombinationschemotherapie mit Adriamycin, Methotrexat, 5-Fluorouracil und Cyclophosphamid beobachtet werden. Das gleiche Therapieschema versagte bei durch N-Methyl-N′-Nitro-N-Nitroso-Guanidin und durch Acetoxymethyl-Methyl-Nitrosamin induzierten Tumoren. Diese Ergebnisse und die Vergleichbarkeit der Chemotherapie autochthoner Tumoren mit experimentellen und klinischen Beobachtungen werden diskutiert.

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Authors and Affiliations

  1. Institute of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 280, 6900, Heidelberg, Federal Republic of Germany

    F. Sych, M. Habs & D. Schmähl

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  1. F. Sych
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  2. M. Habs
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  3. D. Schmähl
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Sych, F., Habs, M. & Schmähl, D. Chemotherapy studies in autochthonous rat tumors intestinal cancer. Z. Krebsforsch. 92, 105–117 (1978). https://doi.org/10.1007/BF00284097

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  • DOI: https://doi.org/10.1007/BF00284097

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