Summary
Tumors of the forestomach were induced in male Sprague-Dawley rats by oral application of acetoxymethyl-methylnitrosamine (AMMN) in single weekly doses of 3.5 mg/kg body weight for 10 weeks. 100±5 days after the beginning of carcinogen treatment exploratory laparotomy was performed. One hundred animals in the same stage of tumor development were divided at random into one control group and four groups treated with cytostatics. Bleomycin (BLM), methotrexate (MTX), 5-fluorouracil (5FU), and 1,2-bis-(2-chloroethyl)-1-nitrosourea (BCNU) were tested in groups of 20 rats each. Only in animals receiving repeated doses of BLM a slight tumor response was observed but no increase in median survival times was seen. No therapeutic effects of the other drugs used were demonstrable.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Carter, S.K., Ichikawa, T., Mathé, G., Umezawa, H.: Fundamental and clinical studies of bleomycin. Gann Monograph No. 19, University of Tokyo Press 1976
Freireich, G.J., Gehan, E.A., Rall, D.P., Schmidt, L.H., Skipper, H.E.: Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother. Rep. 50, 219–244 (1966)
Habs, M., Ang, J., Schmähl, D.: Chemotherapy studies in autochthonous rat tumors: Forestomach and bladder cancer. Z. Krebsforsch. 89, 119–136 (1977)
Schmähl, D.: Die heutige Situation in der experimentellen Chemotherapie von Tumoren. Dtsch. Med. Wochenschr., 91, 2132–2135 (1966)
Schmähl, D.: Entstehung, Wachstum und Chemotherapie maligner Tumoren. Editio Cantor, Aulendorf 1970
Schmähl, D.: Utilization of nitrosamine-induced tumors as models for cancer chemotherapy. In: Chemotherapy, 7, Hellmann, K., Conners, T.A. (eds.): New York: Plenum Publishing Corporation 1976
Schmähl, D., Habs, M.: Lifespan investigations for carcinogenicity of some immune-stimulating, immunodepressive and neurotropic substances in Sprague-Dawley rats. Z. Krebsforsch. 86, 77–84 (1976)
Sych, F., Habs, M., Schmähl, D.: Chemotherapy studies in autochthonous rat tumors: Intestinal cancer. Z. Krebsforsch. 92, 105–117 (1978)
Wiessler, M.: Chemie der Nitrosamine. II. Synthese funktioneller Dimethylnitrosamine. Tetrahedron Letters 30, 2575–2578 (1975)
Zeller, W.J., Eisenbrand, G., Fiebig, H.H.: Chemotherapeutic activity of 2-chloroethyl-nitrosoureas in rat L5222 leukemia: Comparison of bifunctional and water-soluble derivatives with 1,3-bis-(2-chloroethyl)-1-nitrosourea. J. Natl. Cancer Inst. 60, 345–348 (1978)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Habs, M., Schmähl, D. Chemotherapy studies in autochthonous rat tumors: Carcinomas of the forestomach. J Cancer Res Clin Oncol 95, 39–42 (1979). https://doi.org/10.1007/BF00411107
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00411107