Summary
The extent of the relationship between hormone dependence and cytostatica sensitivity of the tumors was examined for primary breast cancers under standardized in vitro conditions. The effects of estradiol and adriamycin on the RNA biosynthesis in the tumor cells were compared on the basis of the 3H-uridine incorporation in a short-term test system. Estradiol particularly influenced the RNA metabolism of higly differentiated carcinomas, whereas adriamycin exhibited the greatest inhibitory effect on the RNA synthesis in the tumor cells of undifferentiated carcinomas. An exact, unequivocal separation of the breast cancers investigated into hormone-sensitive, cytostatica-resistant and hormone-independent, cytostatica-sensitive tumors, however, was not possible under the in vitro conditions chosen.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Baulieu EE (1978) Wirkungsmechanismus der Östrogen. Klin Wochenschr 56:683
Carbone P, Davis TE (1978) Medical Treatment for Advanced Breast Cancer. Seminars in Oncology, Vol. 5,4:417
Carter, StK (1974) The Chemical Therapy of Breast Cancer. Seminars in Oncology, Vol. 1.2, p 131
Chabner AB, Myers ChE, Oliverio VT (1977) Clinical Pharmacology of Anticancer Drugs. Seminars in Oncology Vol. 4:165
Geier GR, Körner, BH, Schuhmann R (1977) Differential Cytology of Breast Cancer. Exp Cell Biol 45:167
Kiang DT, Kennedy BJ (1977) Factors Affecting Estrogen Receptors in Breast Cancer. Cancer 40:1571
Kiang DT, Frenning DH, Goldman AI, Ascensao VF, Kennedy BJ (1978) Estrogen Receptors and Responses to Chemotherapy and Hormonal Therapy in Advanced Breast Cancer. New Engl J Med 14:1330
Lippman ME, Osborne CK, Knazek R, Young N (1977) In vitro model systems for the study of hormone-dependent human breast cancer. New Engl Med 20:154
Lippman ME, Allegra JC, Thompson EB, Simon R, Barlock A, Green L, Huff KK, Do HMT, Aitken SC, Warren R (1978) The Relation between Estrogen Receptors and Response Rate to Cytotoxic Chemotherapy in Metastatic Breast Cancer. New Engl J Med 1:1223
McGuire WL, Horwitz KB, Pearson OH, Segaloff A (1977) Receptors in Breast Cancer. Cancer 39:2934
McGuire WL (1978) Hormone Receptors: Their Role in Predicting Prognosis and Response to Endocrine Therapy. Seminars in Oncology 5:428
Meyer JS, Rao BR, Stevens SC (1977) Low incidence of estrogen receptor in breast carcinomas with rapid rates of cellular replication. Cancer 40:2290
Sanfilippo O, Daidone MG, Di Fronzo G, Silvestrini R (1979) Short-Term Tissue Culture of Human Breast Cancer. Cancer 43:2365
Schlag P, Geier G, Veser J, Breitig D, Betzler M, Herfarth Ch (1978) Prätherapeutische Cytostatica-Sensibilitätstestung des Mammakarzinoms. Langenbecks Arch Chir [Suppl]:231
Schlag P, Geier G, Veser J, Breitig D, Betzler M, Herfarth Ch (1979) Einfluß von Östradiol auf die RNS-Biosynthese von menschlichen Mammakarzinomzellen in vitro. Langenbecks Arch Chir [Suppl]:183
Seeber S, Schmidt CG (1977) Zum Problem der prätherapeutischen Sensibilitätsbestimmung von Tumoren durch Inkorporationsstudien in vitro. Klin Wochenschr 55:1127
Torrelli U (1977) An overlooked aspect of the mechanism of action of most antineoplastic drugs: The inhibition of macromolecular RNA metabolism. Eur J Cancer 13:1363
Volm M, Ways K, Kaufmann M, Mattern J (1979) Pretherapeutic Detection of Tumor Resistance and the Results of Tumour Chemotherapy. Eur J Cancer 15:983
Author information
Authors and Affiliations
Additional information
Supported by Landesverband Baden-Württemberg zur Erforschung und Bekämpfung des Krebses e. V. Stuttgart and Rudoff und Clothilde Eberhardt Stiftung, Ulm
Rights and permissions
About this article
Cite this article
Schlag, P., Veser, J., Geier, G. et al. The influence of estradiol and adriamycin on the RNA biosynthesis in breast cancer. J Cancer Res Clin Oncol 97, 63–70 (1980). https://doi.org/10.1007/BF00411279
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00411279