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Experimentelle Untersuchungen zur Pathogenese der akuten pulmonalen Insuffizienz

An experimental study on the pathogenesis of the acute pulmonary insufficiency

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Research in Experimental Medicine

Summary

Parameters of the lungs as Complicance, PaCO2, PaO2, have been measured in connection with experimental, pathophysiological insults like hematoma, bone marrow intravasation and hemorrhage, in rabbits. Concerning the compliance quotient, a statistically proved decrease was found within that groups, which have had a hematoma. Moreover, the histological picture of the lungs from rabbits with a hematom showed perivascular and intersitial edema and considerable atelectases.

Serum of animals, which have had a hematom for at least 24 h has been fractionated by gel chromatography; low molecular weight substances of the fractionated serum were injected into healthy recipients. Thereafter, measurement of the centralvenous pressure suggests the appearance of substances, pharmacodynamic similar to 5-Hydroxytryptamin, in blood of rabbits with hematom.

Zusammenfassung

Es wurden Funktionsparameter der Lunge (Compliance, PaCO2, PaO2) im Zusammenhang mit experimentell gesetzten pathophysiologischen Faktoren, wie Hämatom, Knochenmarkintravasation und Blutentzug, bei Kaninchen gemessen. Der Compliancequotient ist bei all den Versuchstieren zu den Kontrollen signifikant erniedrigt, bei denen ein Hämatom entweder alleine oder zusammen mit einem der übrigen Faktoren bestand. Zudem zeigt das histologische Bild der Lungen bei den Versuchstieren mit Hämatom perivaskuläre und interstitielle Ödembildung und ausgeprägte Atelektasen. Vergleichende Messungen des zentralvenösen Druckes nach Applikation niedermolekularer Substanzen aus dem Serum vom Hämatomträger an das gesunde Geschwistertier lassen das Auftreten pharmakodynamisch ähnlicher Substanzen, wie dem Serotonin, im Blut von Hämatomträgern vermuten.

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Authors and Affiliations

  1. Institut für Experimentelle Chirurgie, Technischen Universität München, Ismaningerstr. 22, D-8000, München 80, Germany

    W. Erhardt, K. Zänker, W. Tölle & I. Wriedt-Lübbe

  2. BG-Unfallklinik Murnau, D-8110, Murnau, Germany

    J. Probst

Authors
  1. W. Erhardt
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  2. K. Zänker
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  3. W. Tölle
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  4. I. Wriedt-Lübbe
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  5. J. Probst
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Additional information

Diese Arbeit ist Herrn Prof. Dr. G. Blümel zum 50. Geburtstag gewidmet.

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Erhardt, W., Zänker, K., Tölle, W. et al. Experimentelle Untersuchungen zur Pathogenese der akuten pulmonalen Insuffizienz. Res. Exp. Med. 171, 163–172 (1977). https://doi.org/10.1007/BF01851363

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  • DOI: https://doi.org/10.1007/BF01851363

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