Summary
The influence of tracheal lavage with histamine, and of i.v. administration of histamine on bronchospastic response was studied in 16 dogs. Airway response to acetylcholine inhalation was significantly increased after tracheal lavage with high concentrated histamine solution (1%). No influence on airway response was found after (1) tracheal lavage with lower concentrations of histamine and (2) its i.v. administration. The clinical importance of these manifestations is discussed.
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Zimmermann, I., Ulmer, W.T. & Park, S.H. Histamine release into tracheal lumen and bronchial reactivity. Res. Exp. Med. 183, 67–75 (1983). https://doi.org/10.1007/BF01851764
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DOI: https://doi.org/10.1007/BF01851764