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The immunosuppressive effect of streptozotocin-induced diabetes in rats

  • Original Papers
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Research in Experimental Medicine

Summary

Streptozotocin-diabetic isogenous Brown-Norway (BN) rats received heterotopic Wistar-Furth (WF × BN) F1 heart transplants. The functional graft survival time after different duration of diabetes and during insulin-treated diabetes was recorded. Some diabetic rats were challenged with sheep red cells, and their spleens were used in PHA stimulation and plaqueforming assays.

Prolongation in heart transplant survival was found to be independent of the duration of diabetes. The prolongation disappeared promptly when insulin was administered to the diabetic rats. A depression of cellular immunoresponsiveness as measured by PHA stimulation assay was recorded during diabetes. Valid results were not obtained in the plaque-forming assay.

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Authors and Affiliations

  1. Dept. of Experimental Research, University of Lund, General Hospital, S-214 01, Malmö, Sweden

    P. Konrad, B. S. Husberg & L. Nilsson

  2. Dept. of Clinical Microbiology, University of Lund, General Hospital, S-214 01, Malmö, Sweden

    A. Forsgren

Authors
  1. P. Konrad
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  2. A. Forsgren
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  3. B. S. Husberg
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  4. L. Nilsson
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Konrad, P., Forsgren, A., Husberg, B.S. et al. The immunosuppressive effect of streptozotocin-induced diabetes in rats. Res. Exp. Med. 186, 455–462 (1986). https://doi.org/10.1007/BF01852199

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  • DOI: https://doi.org/10.1007/BF01852199

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