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Studies on the Chemoprophylaxis of subperiodicBrugia malayi infection in the leaf monkey (Presbytis melalophos) with diethylcarbamazine citrate

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Abstract

The chemoprophylactic use of diethylcarbamazine citrate at total oral doses of 15–180 mg/kg body weight was tested against subperiodicBrugia malayi infection in the leaf monkey (Presbytis melalophos). A total dose of 45 mg/kg body weight given over 9 days killed all developing over 7 days killed all fourth stage larvae. The minimum effective dose that prevents infection would be 5 mg/kg body weight daily for 7 days every month.

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Authors and Affiliations

  1. Institute for Medical Research, Jalan Pahang, 02-14, Kuala Lumpur, Malaysia

    J. W. Mak & P. K. C. Lim

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  1. J. W. Mak
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  2. P. K. C. Lim
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Mak, J.W., Lim, P.K.C. Studies on the Chemoprophylaxis of subperiodicBrugia malayi infection in the leaf monkey (Presbytis melalophos) with diethylcarbamazine citrate. Z. Parasitenkd. 69, 677–680 (1983). https://doi.org/10.1007/BF00926677

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  • DOI: https://doi.org/10.1007/BF00926677

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