Summary
A No. 15 chromosome with a short arm longer than usual is observed in two phenotypically normal brothers. This chromosome appears to have no visible satellite, shows no N-band staining, and is never involved in satellite association. These results have led us to the conclusion that this chromosome lacks the nucleolus organizer region.
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Bauchinger, M., Schmid, E.: Ein Fall mit balancierter (14p+; 15p-) Translokation. Humangenetik 8, 312–320 (1970)
Cooke, P.: Non-random participation of chromosomes 13, 14 and 15 in acrocentric association. Humangenetik 13, 309–314 (1971)
Cooke, P.: Patterns of secondary association between the acrocentric autosomes of man. Chromosoma (Berl.) 36, 221–240 (1972)
Cuevas-Sosa, A.: Human chromosomology: random association of acrocentrics. Genetica 41, 626–634 (1970)
De Capoa, A., Rocchi, A., Gigliani, F.: Frequency of satellite association in individuals with structural abnormalities of nucleolus organizer region. Humangenetik 18, 111–115 (1972)
Dutrillaux, B., Lejeune, J.: Sur une nouvelle technique d'analyse du caryotype humain. C.R. Acad. Sci. (Paris), t.272 (17 mai 1971)
Evans, H. J., Buckland, R. A., Pardue, H. L.: Location of the genes coding for 18s ribosomal RNA in the human genome. Chromosoma (Berl.) 48, 405–426 (1974)
Faust, J., Vogel, W.: Are N-bands selective staining of specific heterochromatin? Nature (Lond.) 249, 352–353 (1974)
Ferguson-Smith, M. A., Handmaker, S. D.: Observations on the satellited human chromosomes. Lancet 1961 I, 638–640
Funaki, K., Matsui, S., Sasaki, M.: Location of nucleolar organizers in animal and plant chromosomes by means of an improved N-banding technique. Chromosoma (Berl.) 49, 357–370 (1975)
Gagne, R., Tanguay, R., Laberge, C.: Differential staining patterns of heterochromatin in man. Nature (Lond.) New Biol. 232, 29 (1971)
Gigliani, F., De Capoa, A., Rocchi, A.: A marker chromosome number 14 with double satellite observed in two generations: an unbalanced chromosome constitution associated with normal phenotype. Humangenetik 15, 191–195 (1972)
Henderson, A. S., Warburton, D., Atwood, K. C.: Location of ribosomal DNA in the human chromosome complement. Proc. nat. Acad. Sci. (Wash.) 69, N. 11, 3394–3398 (1972)
Lin, C. C., Van de Sande, H., Smink, W. K., Newton, D. R.: Quinacrine fluorescence and Q-banding patterns of human chromosomes. I. Effects of varying factors. Canad. J. Genet. Cytol. 17, 81–92 (1975)
Matsui, S., Sasaki, M.: Differential staining of nucleolus organizers in mammalian chromosomes. Nature (Lond.) 246, 148–150 (1973)
Nakagome, Y.: DNA replication studies of human D-group chromosomes in satellite associations. Cytogenetics 8, 296–306 (1969)
Pardo, D., Luciani, J. M., Stahl, A.: Localisation, par hybridation in situ, des gènes des ARN 28S et 18S dans les chromosomes somatiques humains. Ann. Génét. 2, 105–109 (1975)
Patil, S. R., Lubs, H. A.: Non-random association of human acrocentric chromosomes. Humangenetik 13, 157–159 (1971)
Phillips, R. B.: Inheritance of acrocentric association patterns. Humangenetik 29, 309–318 (1975)
Rocchi, A., De Capoa, A., Gigliani, F.: Double satellites: autoradiographic study of a chromosomal marker observed in two generations. Humangenetik 14, 6–12 (1971)
Schmid, M., Krone, W., Vogel, W.: On the relationship between the frequency of association and the nucleolar constriction of individual acrocentric chromosomes. Humangenetik 23, 267–277 (1974)
Shaw, M. W., Craig, A. P., Ricciuti, F. C.: Random association of human acrocentric chromosomes. Amer. J. hum. Genet. 21, 513–515 (1969)
Yoder, F. E., Bias, W. B., Borgaonkar, D. S., Bahr, G. F., Yoder, I. I., Yoder, O. C., Golomb, H. M.: Cytogenetic and linkage studies of a familial 15p+ variant. Amer. J. hum. Genet. 26, 535–548 (1974)
Zankl, H., Zang, K. D.: Quantitative studies on the arrangement of human metaphase chromosomes. IV. The association frequency of human acrocentric marker chromosomes. Humangenetik 23, 259–265 (1974)
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de Capoa, A., Ferraro, M., Archidiacono, N. et al. Nucleolus organizer and satellite association in a variant D-group chromosome. Hum Genet 34, 13–16 (1976). https://doi.org/10.1007/BF00284428
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DOI: https://doi.org/10.1007/BF00284428