Summary
Sister chromatid exchanges (SCEs) were studied in peripheral human leukocytes from 16 patients with balanced translocations or with unbalanced karyotypes, and from 4 controls. No difference was seen between these two groups of people in the mean number of SCEs per cell, or in the total number of SCEs observed for each pair of autosomes involved in the translocations studied. With this last number no difference from the expected number of SCEs, if one supposes that SCEs follow a random distribution, was seen.
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Beek, B., Obe, G.: The human leukocytes test system. VI The use of sister chromatid exchanges as possible indicators for mutagenic activities. Humangenetik 29, 127–134 (1975)
Bender, M. A., Griggs, H. G., Bedford, J. S.: Mechanisms of chromosomal aberration production. III Chemicals and ionizing radiation. Mutation Res. 23, 197–212 (1974)
Chaganti, R. S. K., Schonberg, S., German, J.: A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc. nat. Acad. Sci. (Wash.) 71, 4508–4512 (1974)
Dutrillaux, B., Lejeune, J.: Sur une nouvelle technique d'analyse du caryotype humain. C.R. Acad. Sci. (Paris) 272, 2638–2642 (1971)
Dutrillaux, B., Laurent, C., Couturier, J., Lejeune, J.: Coloration des chromosomes humains par l'acridine orange après traitement par le 5-bromodéoxyuridine (BudR). C. R. Acad. Sci. (Paris) 276, 3179–3181 (1973)
Gatti, M., Olivieri, G.: The effect of X-Rays on labelling pattern of M1 and M2 chromosomes in Chinese hamster cells. Mutation Res. 17, 101–112 (1973)
Kato, H.: Induction of sister chromatid exchanges by UV light and its inhibition by caffeine. Exp. Cell Res. 82, 383–390 (1973)
Kato, H., Stich, H. F.: Sister chromatid exchanges in ageing and repair-deficient human fibroblasts. Nature 260, 447–448 (1976)
Kihlman, B. A.: Sister chromatid exchanges in vicia faba. II Effects of thiotepa, caffeine and 8-ethoxycaffeine on the frequency of SCE's. Chromosoma (Berl.) 51, 11–18 (1975)
Latt, S. A.: Localization of sister chromatid exchanges in human chromosomes. Science 185, 14–76 (1974)
Paris Conference (1971) Standardization in human cytogenetics. Birth defects: Original article series, vol. VIII, 7. New York: The National Foundation 1972
Perry, P., Evans, H. J.: Cytological detection of mutagen-carcinogen exposure by sister chromatid exchanges. Nature 258, 121–125 (1975)
Poon, P. K., O'Brien, R. L., Parker, J. W.: Defective DNA repair in Fanconi's anaemia. Nature 250, 223–225 (1974)
Sasaki, M. S.: DNA repair capacity and susceptibility to chromsome breakage in xeroderma pigmentosum cells. Mutation Res. 20, 291–293 (1973)
Schnedl, W., Pumberger, W., Czaker, R., Wagenbichler, P., Schwarzacher, H. G.: Increased sister chromatid exchanges events in the human late replicating X. Hum. Genet. 32, 199–202 (1976)
Solomon, E., Bobrow, M.: Sister chromatid exchanges. A sensitive assay of agents damaging human chromosomes. Mutation Res. 30, 273–278 (1975)
Stoll, C., Borgaonkar, D. S., Levy, J.-M.: Effect of vincristine on sister chromatid exchanges of normal human lymphocytes. Cancer Res. 36, 2478–2481 (1976a)
Stoll, C., Kuss, J. J., Schneegans, E.: Inherited t(2q-, 15q+) translocation and Down's syndrome. Clin. Genet. 9, 5–7 (1976b)
Stoll, C., Levy, J.-M., Gardea, A.: Trisomy 9p in a girl whose mother has a translocation t(9;20)(q12;p13). Humangenetik 27, 269–274 (1975a)
Stoll, C., Levy, J.-M.: Identification of a familial Robertsonian translocation t(13q 14q) by means of thermic moderate denaturation. Humangenetik 19, 211–214 (1973a)
Stoll, C., Levy, J.-M.: Translocation de novo t(3;20)(p14;p12) chez une filette. Ann. Génét. 17, 197–199 (1973b)
Stoll, C., Messer, J., Vors, J.: Translocation t(2;14) équilibrée chez une mère et trisomie partielle d'une partie du bras court d'un chromosome No 2 chez deux de ses enfants. Ann. Génét. 17, 193–196 (1974)
Stoll, C., Messer, J., Willard, D.: Trisomy 18 in a child of a women with a familial translocation t(16;19)(q24;p11). (In press 1977)
Stoll, C., Renaud, R., Warter, S.: Avortements spontanés précoces itératifs et translocation t(5;9)(p11;q33). Lyon méd. 233, 307–310 (1975b)
Stoll, C., Rethoré, M. O., Laurent, C., Lejeune, J.: Le contretype de la maladie du cri du chat: la trisomie 5p. Arch. franç. Pédiat. 32, 551–556 (1975c)
Taylor, A. R. M., Metcalfe, J. A., Oxford, J.-M., Harnden, D. G.: Is chromatid-type damage in ataxia telangiectasia after irradiation at Go a consequence of defective repair. Nature 260, 441–443 (1976)
Ueda, N., Uenaka, H., Akematsu, T., Sugiyama, T.: Parallel distribution of sister chromatid exchanges and chromosome aberrations. Nature 262, 581–583 (1976)
Wolff, S., Bodycote, J., Painter, R. B.: Sister chromatid exchanges induced in Chinese hamster cells by U.V. irradiation of different stages of the cell cycle: The necessity for cells to pass through S. Mutation Res. 25, 73–81 (1974)
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Stoll, C., Borgaonkar, D.S. & Bigel, P. Sister chromatid exchanges in balanced translocation carriers and in patients with unbalanced karyotypes. Hum Genet 37, 27–32 (1977). https://doi.org/10.1007/BF00293768
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DOI: https://doi.org/10.1007/BF00293768