Summary
Peripheral blood sister chromatid exchange (SCE) rates in chronic cigarette smokers and in subjects with cancer do not differ from those in healthy nonsmokers. SCE patterns were normal in 69 chronic cigarette smokers, including 62 patients with untreated lung cancer. In three chronic smokers with lung cancer, high SCE levels were related to recent intravenous chemotherapy.
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Chaganti, R. S. K., Schonberg, S., German, J.: A manyfold increase in sister chromatid exchanges in Bloom's syndrome. Proc. Natl. Acad. Sci. USA 71, 4508–4512 (1974)
Galloway, S. M., Evans, H. J.: Sister chromatid exchange in human chromosomes from normal individuals and patients with ataxia telangiectasia. Cytogenet. Cell Genet. 15, 17–29 (1975)
Hatcher, N. H., Brinson, P. S., Hook, E. B.: Sister chromatid exchanges in ataxia telangiectasia. Mutat. Res. 35, 333–335 (1976)
Hollander, D. H., Tockman, M. S., Liang, Y. W., Borgaonkar, D. S., Frost, J. K.: Sister chromatid exchanges in the peripheral blood of habitual cigarette smokers, and in patients with early cancer of the lung. Mammalian Chromosome Newsletter 18, 26 (1977)
Ikushima, T., Wolff, S.: Sister chromatid exchanges induced by light flashes to 5-bromodeoxyuridine-and 5-iododeoxyuridine substituted Chinese hamster chromosomes. Exp. Cell Res. 87, 15–19 (1974)
Kato, H., Shimada, H.: Sister chromatid exchanges induced by mitomycin C. A. new method of detecting DNA damage at chromosomal level. Mutat. Res. 28, 459–464 (1975)
Kato, H., Stich, H. F.: Sister chromatid exchanges in ageing and repair-deficient human fibroblasts. Nature 260, 447–448 (1976)
Lacassie, Y., Fu, W., Borgaonkar, D. S.: Chromosome abnormalities and sister chromatid exchanges (SCE) in senescence. Am. J. Hum. Genet. 27, 57A (1975)
Latt, S. A.: Microfluorometric detection of desoxyribonucleic acid replication in human metaphase chromosomes. Proc. Natl. Acad. Sci. USA 70, 3395–3399 (1973)
Latt, S. A.: Sister chromatid exchanges, indices of human chromosome damage and repair: detection by fluorescence and induction by mitomycin C. Proc. Natl. Acad. Sci. USA 71, 3162–3166 (1974)
Latt, S. A., Stetten, G., Juergens, L. A., Buchanan, G. R., Gerald, P. S.: Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia. Proc. Natl. Acad. Sci USA 72, 4066–4070 (1975)
Morgan, W. F., Crossen, P. E., The incidence of sister chromatid exchanges in cultured human lymphocytes. Mutat. Res. 42, 305–312 (1977)
Perry P., Evans, H. J.: Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange. Nature 258, 121–125 (1975)
Perry, P., Wolff, S.: New Giemsa method for the differential staining of sister chromatids. Nature 251, 156–158 (1974)
Rudiger, H. W., Kohl, F. V., Mangels, W., Wechert, P. von, Bertram, C. R., Wohler, W., Passarge, E.: Benzpyrene induces sister chromatid exchanges in cultured human lymphocytes. Nature 262 290–292 (1976)
Schonwald, A. D., Bartram, C. R., Rudiger, H. W.: Benzpyrene-induced sister chromatid exchanges in lymphocytes of patients with lung cancer. Hum. Genet. 36, 261–264 (1977)
Solomon, E., Bobrow, M.: Sister chromatid exchanges — A sensitive assay of agents damaging human chromosomes. Mutat. Res. 30, 273–278 (1975)
Stetka, D. G., Wolff, S.: Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. I. In vivo test for compounds requiring metabolic activation. Mutat. Res. 41, 333–342 (1976)
Stoll, C., Borgaonkar, D. S., Levi, J.-M.: Effect of vincristine on sister chromatid exchanges of normal human lymphocytes. Cancer Res. 36, 2710–2713 (1976)
Wolff, S., Bodycote, J., Thomas, G. H., Cleaver, J. E.: Sister chromatid exchange in xeroderma pigmentosum cells that are defective in DNA excision repair or post-replication repair. Genetics 81, 349–355 (1975)
Wynder, E. L., Hoffman, D.: Experimental tobacco carcinogenesis. Science 162, 862–871 (1968)
Yu, C. W., Borgaonkar, D. S.: Normal rate of sister chromatid exchange in Down's syndrome. Clin. Genet. 11, 397–401 (1977)
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Hollander, D.H., Tockman, M.S., Liang, Y.W. et al. Sister chromatid exchanges in the peripheral blood of cigarette smokers and in lung cancer patients; and the effect of chemotherapy. Hum Genet 44, 165–171 (1978). https://doi.org/10.1007/BF00295409
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DOI: https://doi.org/10.1007/BF00295409