Summary
The frequency of sister chromatid exchanges (SCEs) in the centromere of chromosomes involved in a whole-arm translocation t(1;19) was evaluated in altogether 911 metaphases of translocation carriers (n=5) and of normal controls (n=6). Comparison of the two groups reveals no significant differences in the SCE rate (x 2=3.06, n f =1). The question as to whether the possible increase of the SCE rate at the translocation point could be detected by light microscopy is discussed. Parameters included in the discussion are the ratio of the SCE frequency at the translocation point to the SCE frequency at any of the possible breakage points in the centromeric region and the number of possible breakage points in the centromeric region.
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References
Alhadeff, B., Cohen, M. M.: Frequency and distribution of sister chromatid exchanges in human peripheral lymphocytes. Isr. J. Med. Sci. 12, 1440–1448 (1976)
Born, M., Wolf, E.: Principles of optics. Oxford: Pergamon Press 1970
Chaganti, R. S. K., Schonberg, S., German, J.: A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc. Natl. Acad. Sci. USA 71, 4508–4512 (1974)
Coulson, C. A.: Valence. Oxford: Oxford University Press 1962
Fonatsch, C.: A technique for simultaneous demonstration of G bands and sister chromatid exchanges. Cytogenet. Cell Genet. 23, 144–146 (1979)
Fonatsch, C., Flatz, S. D., Weitzel, E.: Partial trisomy 13 plus partial trisomy 4q due to unusual segregation of translocation chromosomes. Clin. Genet. 15, 176–182 (1979)
Michalová, K., Málková, J., Urban, J.: Cell division and sister chromatid exchanges in 45,X/46,X,i(Xq) mosaicism. Hum. Genet. 39, 87–90 (1977)
Perry, P., Evans, H. J.: Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange. Nature 258, 121–125 (1975)
Perry, P., Wolff, S.: New Giemsa method for the differential staining of sister chromatids. Nature 251, 156–158 (1974)
Schober, A. M., Fonatsch, C.: Balanced reciprocal whole-arm translocation t(1;19) in three generations. Hum. Genet. 42, 349–352 (1978)
Stoll, C., Borgaonkar, D. S., Bigel, P.: Sister chromatid exchanges in balanced translocation carriers and in patients with unbalanced karyotypes. Hum. Genet. 37, 27–32 (1977)
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Schober, A.M., Fonatsch, C. & Schober, O. Frequency of sister chromatid exchanges in a balanced reciprocal whole-arm translocation. Hum Genet 51, 93–97 (1979). https://doi.org/10.1007/BF00278297
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DOI: https://doi.org/10.1007/BF00278297