Summary
Frequencies of transferrin phenotypes and genes were determined in a sample of 319 randomly selected subjects from the population of Rome. Disc electrophoresis on acrylamide gel columns was adopted for the phenotype identification. A statistical analysis on these and all the data so far collected in other areas of the world would suggest that a high degree of homogeneity is present among white populations, while a certain degree of heterogeneity exists among coloured populations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alciati, G., I. Baschieri, G. A. Benedetti e G. Spedini: Le transferrine seriche dei negri N'Zakara. Ric. Sci. 33, 299–308 (1964).
Angelopoulos, B., A. Kalos, and E. Danopoulos: Transferrin variants in Greeks. J. Med. Genet. 4, 31–32 (1967).
Arends, T.: Transferrin groups in South American Indians. Bibl. haemat. (Basel) 23, 405–411 (1965).
Beckman, L., and O. Johannsson: Haptoglobins and transferrins in the Icelandic population. Acta genet. (Basel) 17, 341–344 (1967).
Bowman, J. E.: Haptoglobin and transferrin differences in some Iranian populations. Nature (Lond.) 201, 88–89 (1964).
Cooper, D. W., H. Lander, and R. L. Kirk: DAdelaide: A new transferrin variant in man. Nature (Lond.) 204, 102–103 (1964).
Giblett, E. R.: The plasma transferrins, in Steinberg, A. G., and A. G. Bearn: Progress in medical genetics. Vol. II, pp. 34–46. New York-London: Grune & Stratton 1962.
—, C. G. Hickmans, and O. Smithies: Serum transferrins. Nature (Lond.) 183, 1589–1590 (1959).
—, A. G. Motulski, and G. R. Fraser: Population genetic studies in the Congo. IV-Haptoglobin and transferrin serum groups in the Congo and in other African populations. Amer. J. hum. Genet. 18, 553–558 (1966).
Glen-Bott, A. M., H. Harris, E. B. Robson, A. G. Bearn, and W. C. Parker: Transferrin DWigan, Acta genet. (Basel) 14, 52–55 (1964).
Harris, H., D. G. Pennington, E. B. Robson, and C. R. Scriver: A further genetically determined transferrin variant in man. Ann. hum. Genet. 24, 327–331 (1960).
—, E. B. Robson, and M. Siniscalco: Beta-globulin variants in man. Nature (Lond.) 182, 452 (1958).
Lai, L. Y. C.: A new transferrin in New Guinea. Nature (Lond.) 198, 589 (1963).
Levene, M.: On a matching problem arising in genetics. Ann. Math. Stat. 20, 91–94 (1949).
Ornstein, L.: Reagent for demonstration of transferrin with disc electrophoresis. Eastman Organic Chemicals Information Sheet L 20—1164 (1966).
Parker, W. C., and A. G. Bearn: Haptoglobin and transferrin variations in humans and primates: two new transferrins in Chinese and Japanese populations. Ann. hum. Genet. 25, 227–241 (1961).
—: Studies on the transferrins of adult serum, cord serum and cerebrospinal fluid: the effect of neuraminidases. J. exp. Med. 115, 83–115 (1962).
Prochnika, B.: The frequencies of transferrin types in the population of Crakow. Acta genet. (Basel) 11, 106–110 (1966).
Poulick, M. D., and O. Smithies: Comparison and combination of the starch-gel and filterpaper electrophoresis methods applied to human sera: two dimensional electrophoresis. Biochem. J. 68, 636–643 (1958).
Salzano, F. M., and H. E. Sutton: Haptoglobin and transferrin types of Indians from Santa Catarina, Brazil. Amer. J. hum. Genet. 17, 280–289 (1965).
Sanford, R., A. E. P. Grimmo, and S. Lee: The haptoglobin and transferrin types of some Cantonese in Hong-Kong. Vox Sang. (Basel) 11, 106–107 (1966).
Seppälä, M., E. Ruoslhati, and O. Mäkelä: Inheritance and genetic linkage of Gc and transferrin groups. Acta genet. (Basel) 17, 47–54 (1967).
Serafini, N. A.: Nota sull'applicazione della tecnica dell'elettroforesi a disco in gel di acrilamide per l'identificazione dei fenotipi aptoglobinici. Acta med. Romana 2, 448–454 (1966).
Smith, C. A. B.: Note on gene frequency estimation with multiple alleles. Ann. hum. Genet. 31, 99–107 (1967).
Smithies, O.: Variations in human serum beta-globulins. Nature (Lond.) 180, 1482 (1957).
—: Third allele at the serum beta-globulin locus in humans. Nature (Lond.) 181, 1203–1204 (1958).
—: An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. Biochem. J. 71, 585–587 (1959).
Steinberg, A. G., L. Y. C. Lai, G. H. Vos, R. B. Singh, and T. E. Lim: Genetic and population studies of the blood types and serum factor among Indians and Chinese from Malaya. Amer. J. hum. Genet. 13, 355–371 (1961).
Van Roos, G., M. van Sande, and M. Druet: Groupes d'haptoglobine et de transferrine dans des populations Africaines et Européennes. Ann. soc. belge Méd. trop. 43, 511–537 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Serafini, N.A., Serra, A. Plasma transferrin phenotype and gene frequencies in the population of Rome (Italy). Hum Genet 6, 142–147 (1968). https://doi.org/10.1007/BF00297722
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00297722