Summary
Paracentric inversion of chromosome 7 was found in a female infant with multiple malformations and in her phenotypically normal mother. Examination of prometaphase chromosomes revealed an additional small dark band on the inverted chromosome 7 of the girl. It was assumed that an unequal crossing over at the base of a meiotic loop of chromosome 7 had occurred in the mother and resulted in a tiny interstitial duplication in the girl.
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Hoo, J.J., Lorenz, R., Fischer, A. et al. Tiny interstitial duplication of proximal 7q in association with a maternal paracentric inversion. Hum Genet 62, 113–116 (1982). https://doi.org/10.1007/BF00282296
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DOI: https://doi.org/10.1007/BF00282296