Summary
In a patient affected by ataxia telangiectasia (AT), an invading clone with a t(14;14) was found in PHA-, but not in pokeweed-stimulated, lymphocytes. With high resolution R-banding, the proximal breakage was visualized at the junction of bands q11.1–q11.2. This breakpoint differs from that (q12) of noninvading rearrangements of chromosome 14 in AT and non-AT patients. These differences are discussed.
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Aurias, A., Dutrillaux, B. & Griscelli, C. Tandem translocation t(14;14) in isolated and clonal cells in ataxia telangiectasia are different. Hum Genet 63, 320–322 (1983). https://doi.org/10.1007/BF00274754
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DOI: https://doi.org/10.1007/BF00274754